The patient A27 year oldman with a six month history of mild but progressive headache visited his general practitioner and was found to have a blood pressure of 178/ 108mmHg.He had an unremarkablemedical history, but his father had had high blood pressure and had died from a stroke at age 45 years. Clinical examination with a particular emphasis on the cardiovascular system including funduscopy...

A 77-year-old man presented with an inferior hemivisual field defect in the left eye. Funduscopy revealed well demarcated retinal edema of the superior quadrant resembling hemicentral retinal artery occlusion. Further, the upper and inferior retinal arteries emerged separately from the optic disc. Fluorescein angiography demonstrated a marked filling delay of the upper retinal artery. We repeat...

A 54-year-old woman with multiple sclerosis, on natalizumab, reported 2 weeks of left eye redness and blurry vision, previously diagnosed as conjunctivitis. Visual acuity was 20/125. Funduscopy revealed progressive outer retinal necrosis (figure 1), a viral retinitis of immunocompromised patients that frequently causes vision loss. Sequential bilateral involvement is common. Etiologies include ...

cranial neoplasms seldom calcify and classic histopathological series has revealed the incidence of calcification in brain metastasis to be just about 1% (Sastre-Garriga et al., 2000); furthermore, development of breast cancer in men is a rarity. A 30-year-old man with two year history of breast cancer and chemotherapeutic treatment was admitted in emergency room for the evaluation of moderate ...

CASE REPORT A 59 year-old male with choroidal melanoma in the left eye who underwent plaque brachytherapy (iodine 125). One week after surgery, massive exudation with retinal detachment and lipid exudation was observed. Evolution was assessed with funduscopy and ultrasound every month. Nine months after surgery transpupillary thermotherapy (TTT) was performed over the fluid-free irradiated resi...

CASE REPORT We report a case of a 12-year-old patient who complained about visual disturbances in left eye for 6 months. His visual acuity was 1/0.9, funduscopy in left eye revealed a free-floating cyst in the anterior vitreous. Magnetic resonance showed a low intense image in T1, and B-scan ultrasound confirmed a hypoechogenic cyst of 3.2 × 4.3 mm; ultrasound biomicroscopy revealed a normal ci...

A 50-year-old woman with myotonic dystrophy (MD) presented with bilateral blurred vision. Visual acuity was 16/ 20 in both eyes. Slit lamp examination showed cortical and posterior subcapsular opacities in both lenses. Funduscopy showed depigmented changes at the macula, however, details were unclear due to the presence of cataract (Picture 1). Fundus autofluorescence (FAF) imaging clearly defi...

A 61-year-old man presented with a 4-month history of progressive vision loss and paresthesia between the right L2-L4 dermatome. Funduscopy revealed severe bilateral papilledema (figure 1). Head CT showed mild hydrocephalus. CSF from a lumbar puncture at the L4-L5 level was xanthochromic with an elevated protein level (4,350 mg/dL). Lumbar spine MRI demonstrated a large intradural tumor at the ...

Methods After detailed clinical characterization including funduscopy and optic coherence tomography, exome sequencing analysis was performed in a proband of Dutch origin with non-syndromic autosomal recessive RP. Identified mutations were tested for segregation within the family and in a large cohort of genetically unsolved RP patients. Upon identification of mutations in MVK, encoding mevalon...