We have previously reported that the level of 5-HT in the masseter muscle is increased in patients with fibromyalgia as compared with healthy subjects and that high intramuscular level of 5-HT is associated with muscle pain. We have also reported that injection of the 5-HT(3) receptor antagonist granisetron (GRA) into the masseter muscle of healthy subjects reduced pain induced by 5-HT and abol...

Glycyrrhizin, an abundant bioactive component of the medicinal licorice root is rapidly metabolized by gut commensal bacteria into 18β-glycyrrhetinic acid (GRA). Either or both of these compounds have been shown to have antiviral, anti-hepatotoxic, anti-ulcerative, anti-tumor, anti-allergenic and anti-inflammatory activity in vitro or in vivo. In this study, the ability of GRA to modulate immun...

Abstract: Optimal siting of electric vehicle charging stations (EVCSs) is crucial to the sustainable development of electric vehicle systems. Considering the defects of previous heuristic optimization models in tackling subjective factors, this paper employs a multi-criteria decision-making (MCDM) framework to address the issue of EVCS siting. The initial criteria for optimal EVCS siting are se...

In this paper, a graphical algorithm (GrA) is presented for an investment optimization problem. This algorithm is based on the same Bellman equations as the best known dynamic programming algorithm (DPA) for the problem but the GrA has several advantages in comparison with the DPA. Based on this GrA, a fully-polynomial time approximation scheme is proposed having the best known running time. Th...

This study creates a framework to aid in the sustainability of maintenance strategies. The was created using expertise from industry and academia. Using this knowledge, three multi-criteria tools were chosen for strategies evaluation. include grey relational analysis (GRA) techniques, additive ratio assessment (ARAS), step-wise weight (SWARA). In production system, they used assess four planned...

Glucocorticoid remediable aldosteronism (GRA) is rare familial form of primary aldosteronism characterized by a normalization of hypertension with the administration of glucocorticoids. We present a case of GRA and thoracoabdominal aneurysm complicated by multiple aortic dissections requiring complex surgical and endovascular repairs. Registry studies have shown a high rate of intracranial aneu...

AIM The aim of this paper is to explore issues surrounding the implementation of a generic rehabilitation assistant (GRA) to provide ward-based rehabilitation after critical illness. BACKGROUND Following critical illness a range of both physical and psychological problems can occur that include muscle wasting and weakness, fatigue, reduced appetite, post-traumatic stress, anxiety and depressi...

the purpose of the present study was to explore the passive and electrically assisted transdermal transport of granisetron hydrochloride (gra) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. in this study, iontophoretic permeation of gra through guinea pig skin...