Epithelial dysplasia of gall bladder is an important precancerous lesion of gall bladder carcinogenesis. To investigate the frequency of K-ras gene mutation in gall bladder carcinoma and dysplasia, K-ras codon 12 mutations were investigated by the polymerase chain reaction/restriction enzyme based method following direct sequencing. Mutation was detected in 59% (30 of 51) of gall bladder carcin...

The formation of tumors in tissues of higher plants by the crown-gall organism, (Phytomonas tumefaciens), is influenced by several factors. First, the bacteria themselves must be virulent. Avirulent strains of the crown-gall organism will not produce a gall in susceptible tissue unless that tissue is also stimulated by a growth hormone (1, 10) or by products from a gall produced by fully virule...

In a prospective study of gall stone related deaths in a single Health District, the biliary tract was examined at necropsy in 1701 cases and 8078 death certificates were searched. Gall stones were identified as the cause of death in only 21 cases (0.26%) but in 291 subjects found to have gall stones or cholecystectomy at necropsy, the mortality was 3.4%. The necropsy prevalence of gall stones ...

Hypersection of gall bladder mucus is associated with gall stone formation in animal models. Aspirin inhibits both mucus synthesis and secretion, prevents gall stone formation in animals and reduces gall stone recurrence in man after dissolution therapy. Mucus biosynthesis in human gall bladder mucosal explants is inhibited by aspirin in vitro. We have studied the effects of aspirin in vivo. Fi...

Cajal bodies (CBs, formerly coiled bodies) and nucleoli share several biological features, including close physical proximity, overlapping protein profiles, disassembly during mitosis, and association with specific chromosomal loci (reviewed by Gall, 2000). Despite these similarities, biogenesis of the two organelles appears to be quite different. Nucleoli normally form on chromosomes at the nu...

1. The human gall bladder acidifies the bile. In this respect its action is similar to that of the gall bladders of lower animals, previously described by other workers. 2. The hydrogen ion concentration of gall bladder bile is increased considerably in cases of obstruction of the common or cystic ducts. The highest values were found following complete obstruction. 3. The occurrence of gall sto...

BACKGROUND Gall bladder functions are modulated by neurones intrinsic to the organ. Data are available on the neurochemical composition of intrinsic and extrinsic nerves innervating the gall bladder but are lacking on specific functional classes of gall bladder neurones. AIMS To characterise the intrinsic motor neurones of the gall bladder and identify their roles using pharmacological techni...

Herein we report results of transplant experiments that link variation in host plant quality to herbivore fitness at the local scale (among adjacent plants) with the process of local (demic) adaptation at the landscape scale to explain the observed distribution of the specialist gall former Belonocnema treatae (Hymenoptera: Cynipidae) within populations of its host plant, Quercus fusiformis. Fi...

IntrOductIOn Diverticulum of the gall bladder is an important but distinct anatomical entity with significant clinical implications. Congenital diverticulum of the gall bladder is one of the rarest of all anomalies, corroborated by its very low incidence and infrequent reports and references in the literature [1]. Diverticulum can be of congenital or acquired variety. The congenital type contai...