abstract background: radiosensitizer drugs are used to enhance the efficiency of radiotherapy. some nanoparticles can be considered as radiosensitizers, because they enhance cytotoxicity due to oxidative stress and increase free radical yield, especially ros , within cells resulting to cell death. methods: in this study, synergistic effect of tio 2 nanoparticles was evaluated in presence of 60 ...

background: to evaluate the effects of hyperthermia (ht) on the frequency of chromosomal aberrations induced by a low dose of neutron or γ-rays in human peripheral blood lymphocytes. materials and methods: blood samples were exposed to ht (41.5°c for 30 and 60min, 43°c for 15 and 30min), 10 cgy neutron or γ-rays, ht + neutron/γ, and neutron/γ + ht. after standard cell culture, harvesting, fixat...

background: a radioprotective effect of amifostine as well as its ability to modulate the level of spontaneous and gamma-irradiation-induced genetic changes on human peripheral blood lymphocytes has been investigated . amifostine, known as a potent radical scavenger, has been introduced as the most effective radioprotector, yet it is not completely approved for the clinical use. however, furthe...

us damages to the ovary storage and the matrix muscle state. some of these patients may admit to infertility clinics for having pregnancy and on the other hand hormonal administration for superovulation induction is a routine procedure in assisted reproduction technology (art) clinics.objective: this study aimed to investigate fertility and fetuses of hormone treated super ovulated female mice ...

objective: the purpose of this study was to observe the effects of methoxyamine (mx) on the cytotoxic effects and dna damage caused by 5-fluorouoracil (5-fu), in combination with gamma-rays in human colon cancer cell line. materials and methods: in this experimental study, ht29 cells were cultured as a monolayer and treated with different concentrations of 5-fu along with 1 mm mx for 24 h. afte...

Here we present direct evidence for the vital role of RecO in Deinococcus radiodurans's radioresistance. A recO null mutant was constructed using a deletion replacement method. The mutant exhibited a growth defect and extreme sensitivity to irradiation with gamma rays and UV light. These results suggest that DNA repair in this organism occurs mainly via the RecF pathway.

Introduction: Radiation countermeasures are defined as use of an agent to minimize the deleterious effects of radiation therapy by administering the compound after the radiation exposure has occurred, regardless of toxicity. In spite of extensive study in this field, yet there is no suitable radioprotector introduced. In this study two naturally occurring antioxidants were stu...

In order to assess the responses of Hashemi rice genotype and its advanced mutant line under salinity stress of 100 mM Sodium chloride (NaCl) for three and six days the shoot samples were taken for biochemical analysis. This experiment was performed in split plot based on randomized complete block design with three replications. The main factor was factorial combination of saline treatmen...

Very high energy {\gamma}-rays are one of the most important messengers non-thermal Universe. The major motivation very {\gamma}-ray astronomy is to find sources cosmic rays. Several astrophysical known accelerate rays energies under extreme conditions. produced at these sites or near through interactions in surrounding medium close sources. Gamma-rays, being neutral, travel a straight line and...