Light-evoked postsynaptic currents (lePSCs) were recorded from ON, OFF and ON-OFF ganglion cells in dark-adapted salamander retinal slices under voltage clamp conditions, and the cell morphology was examined using Lucifer yellow fluorescence with confocal microscopy. The current-voltage relations of the lePSCs in all three types of ganglion cells are approximately linear within the cells' physi...

The postsynaptic potentials (PSPs) that form the ganglion cell light response were isolated by polarizing the cell membrane with extrinsic currents while stimulating at either the center or surround of the cell's receptive field. The time-course and receptive field properties of the PSPs were correlated with those of the bipolar and amacrine cells. The tiger salamander retina contains four main...

We quantified the spatial distribution of presumed ganglion cells and displaced amacrine cells in unstained whole mounts of six young normal human retinas whose photoreceptor distributions had previously been characterized. Cells with large somata compared to their nuclei were considered ganglion cells; cells with small somata relative to their nuclei were considered displaced amacrine cells. W...

The development of the nervous system is dependent on a complex set of signals whose precise co-ordination ensures that the correct number of neurones are generated. This regulation is achieved through a variety of cues that influence both the generation and the maintenance of neurones during development. We show that in the chick embryo, stratified retinal ganglion cells (RGCs) are themselves ...

Thirteenth Annual Vision Research Conference April 30–May 1–2, 2010 Convention Center Ft. Lauderdale, FL The 13th Annual Vision Research Conference, ‘‘Retinal ganglion cells: development, function, and disease’’ was held at the Convention Center at Ft. Lauderdale, Florida, April 30–May 1, 2010. The meeting was very well attended (294 registrations), and 39 invited speakers reviewed the latest d...

Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss. The common site of damage to retinal ganglion cells is thought to be at the optic nerve head, however evidence from other optic neuropathies and neurodegenerative disorders suggests that dendritic structures...

PURPOSE The purpose of this study was to study the pattern of foveal ganglion cell loss in experimental glaucoma. METHODS Retinal ganglion cell size and number in the foveal region of seven monkey eyes with experimental glaucoma was determined and compared to normal monkey eyes. Serial sections of macular retina were studied in two regions: the plateau of peak density of ganglion cells (800-1...

Retinal ganglion cell loss was investigated in the retinae of albino quails before and after the development of glaucoma. The isodensity maps of ganglion cells, the total number of ganglion cells, and the histograms of the cell size in the central region of the retina were similar between albino quails without glaucoma and pigmented quails. However, ganglion cells in the intermediate and periph...