Pancreatic cancer, the fourth leading cause of cancerrelated death, possesses a very poor prognosis and an extremely high death/incidence ratio of approximately 99%, which is not only due to its little possibility of surgical resection but also the increasing resistance to almost all chemotherapeutic agents (Lange et al., 2012; Jiang et al., 2012; Ren et al., 2012). Therefore multidisciplinary ...

Protective effect of garlic on the development of cancer has been reported in the in vitro and in vivo experimental studies; however, few human epidemiologic studies have evaluated the relationship. A population-based case-control study has been conducted in a Chinese population from 2003 to 2010, with the aim to explore the association between raw garlic consumption and lung cancer. Epidemiolo...

Studies on the effects of garlic (Allium sativum) on hyperlipidemia have demonstrated somewhat controversial results and there have been few studies on its enzymatic mechanism. The purpose of this study was to assess the effect of garlic on the liver phosphatidate phosphohydrolase (PAP) activity, plasma lipid levels, malondialdehyde (MDA) and plasma antioxidant in rats fed either by normal or h...

Herbs and dietary supplements can have significant physiological effects. Garlic (Allium sativum) has shown beneficial lipid effects in a majority of trials; dried garlic preparations are superior to oil preparations. There is preliminary evidence that indicates that hawthorn (Crataegus species) may provide benefits in congestive heart failure. Coenzyme Q also may be of benefit in congestive he...

Garlic oil (GO) is behaves as a nutraceutical compound; however, its application is limited due to its pungency, undesirable aroma, low stability and solubility. The physicochemical properties of GO are certainly key parameters in the encapsulation process. Therefore, the aim of the current work was to study the effect of different extraction procedures such as solvent extraction, distillation ...

Background: Hypercholesterolemia is associated with an increased risk of heart disease. In this study, we investigated the antihyperlipidemic effects of garlic (Allium sativum L.) in rat models of hypercholesterolemic. Methods: Wistar male rats were randomly divided into 4 diet groups with garlic supplementation. Male Wistar rats were fed by standard pellet diet (group I), standard diet supplem...

To investigate the factors influencing the supercritical CO2 extraction of garlic oil, and to explore the inhibitory effect of allicin on human hepatoma HepG2 cell growth. Appropriate combination of process parameters for supercritical CO2 extraction of garlic oil was identified through orthogonal experiment. Human hepatoma HepG2 cells were cultured in vitro, and changes in growth of allicin-tr...

The effect of oral ingestion of garlic oil was studied in 20 healthy human volunteers in a double-blind, two period, cross-over trial. The individuals were randomly divided into two groups. Each group rotated for four week periods through 2 different sequences of oral supplementation including: 18 mg of garlic oil (extracted from 9 grams of fresh garlic) and placebo. The amount of platelet aggr...

In this study, we investigated the effect of savory (Satureja hortensis) essential oil, garlic(Allium sativum) powder, and garlic aqueous extract on fungal load of poultry feed. Tothis end, savory essential oil and garlic aqueous extract each amounting 62.5, 125, and250 μl/ml and mg/ml, respectively, per kilogram of feed and garlic powder amounting2.5, 5, and 10 g/kg of feed were used. One and ...

BACKGROUND In the present study, we investigated the effects of oil products from two Allium species: Allium sativum (garlic) and Allium hookeri (Chinese chives) on cell proliferation and neuroblast differentiation in the mouse dentate gyrus. METHODS Using corn oil as a vehicle, the essential oil from garlic (10 ml/kg), or Chinese chives (10 ml/kg) was administered orally to 9-week-old mice o...