We treated a 55-year-old male patient with Wegener's granulomatosis (WG) asseciated with frequent gastric bleeding from multiple ulcerative lesiens. Only a few cases of frequent hemorrhaging of peptic ulcers associated with WG have been reported. In our case, a gastric biopsy showed mononuclear cell infi1tratipn in the submucosal areeq without granulomas or vasculitis. An endoscopic, maneuver, ...

We treated a 55-year-old male patient with Wegener's granulomatosis (WG) asseciated with frequent gastric bleeding from multiple ulcerative lesiens. Only a few cases of frequent hemorrhaging of peptic ulcers associated with WG have been reported. In our case, a gastric biopsy showed mononuclear cell infi1tratipn in the submucosal areeq without granulomas or vasculitis. An endoscopic, maneuver, ...

Correspondence to: Professor R E Clouse, Division of Gastroenterology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8124, St Louis, MO 63110, USA; [email protected] _________________________ INTRODUCTION In 1990 we asked clinicians attending a symposium during the annual meeting of the American Gastroenterological Association how many were using psychopharmacolo...

Gastrointestinal (GIs) cancers are among the most common causes of cancer related death, and hence importance for identification novel prognostic/predictive biomarkers detection patients at an early stage, using these to identify targeted therapies improve efficacy existing chemotherapeutic regimens. Programmed cell death 1 has been reported as a potential target in several malignancies, target...

Inflammatory bowel disease (IBD) is an immune-mediated inflammatory condition causing inflammation of gastrointestinal and systemic cells, with an increasing prevalence worldwide. Many factors are known to trigger and maintain inflammation in IBD including the innate and adaptive immune systems, genetics, the gastrointestinal microbiome and several environmental factors. Our knowledge of the in...

Chemoprevention of gastrointestinal tumors uses natural or synthetic agents to arrest, retard or reverse the carcinogenesis process. The prospect of prevention is clearly appealing, especially for colorectal cancer (CRC), that represents the second most common cause of cancer-related death in the Western world. Aspirin is the best studied chemopreventive agent for CRC, with randomized trials de...

Correspondence to: Professor R E Clouse, Division of Gastroenterology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8124, St Louis, MO 63110, USA; [email protected] _________________________ INTRODUCTION In 1990 we asked clinicians attending a symposium during the annual meeting of the American Gastroenterological Association how many were using psychopharmacolo...

Management of anticoagulant and antiplatelet therapy is a common clinical problem in case urgent or elective gastrointestinal endoscopic procedures. Anticoagulants agents are widely used drugs for cardiovascular prevention reducing the risk thromboembolic events. Gastrointestinal bleeding represents serious complication their use. It’s recommended temporary interruption anticoagulants clinicall...

The motility of gastrointestinal tract is regulated by classical neurotransmitters, neuropeptides, and humoral agents. Two novel human cDNAs have been cloned based on their sequence similarity to a frog skin secretion protein, Bv8, and a nontoxic protein of mamba snake venom. These human cDNAs encode two secreted proteins of 86 and 81 amino acids. Northern blot hybridization has revealed that t...