coagulaon factor xiii gene, protein structure and funcon coagulaon factor xiii (fxiii) is a tetrameric (fxiii- a2b2) pro-transglutaminase enzyme with an essenal role in the final stage of coagulaon cascade by cross linking the fibrin monomers and stabilizing the fibrin clot. congenital fxiii deficiency is a rare bleeding disorder, with an autosomal recessive trait inheritance, and a freque...

Gastrointestinal complications frequently occur in patients admitted to the intensive care unit. Of these, ulceration and bleeding related to stress-related mucosal disease (SRMD) can lengthen hospitalization and increase mortality. The purpose of this review is to discuss the many risk factors and underlying illnesses that have a role in the pathophysiology of SRMD and evaluate the evidence pe...

Background:Upper gastrointestinal (GI) bleeding remains a problem in critically ill-newborns. The use of H2 blockers, by maintaining gastric pH ³ 4, reduces the risk of stress-ulceration and gastric hemorrhage. This study therefore, has evaluated the effects of short-term prophylactic‎ ranitidine in controlling gastric pH and prevention of GI bleeding in neonates. Methods: This randomized contr...

Prevention of thromboembolic complications is the main goal in patients with atrial fibrillation. Anticoagulant therapy used as prophylaxis, and direct oral anticoagulants are preferred. However, this associated a risk bleeding, among which gastrointestinal bleeding takes leading place. Proton pump inhibitors now widely prophylaxis for upper bleedings, but when long-term, may be number adverse ...

OBJECTIVE To assess use of stress ulcer prophylaxis in patients admitted to five pediatric intensive care units (PICUs) in Porto Alegre, Brazil. METHODS This was a multicenter, prospective, cross-sectional observational study. PICUs were visited on randomly defined days between April 2006 and February 2007, and the medical records of admitted patients were reviewed. Patients whose records had...

background: upper gastrointestinal (gi) bleeding remains a problem in critically ill-newborns. the use of h 2 blockers, by maintaining gastric ph ³ 4, reduces the risk of stress-ulceration and gastric hemorrhage. this study therefore, has evaluated the effects of short-term prophylactic‎ ranitidine in controlling gastric ph and prevention of gi bleeding in neonates.   methods: this randomized c...

BACKGROUND Stress ulcer prophylaxis is considered standard of care in many critically ill patients in the intensive care unit (ICU). However, the quality of evidence supporting this has recently been questioned, and clinical equipoise exists. Whether there is overall benefit or harm of stress ulcer prophylaxis in adult hospitalised acutely ill patients is unknown. Accordingly, we aim to assess ...

background this study aimed to determine the common etiologies and character­istics of lower gastrointestinal (gi) bleeding in children from southern iran. methods this five-year prospective cross-sectional study was performed from march 2006 to march 2011 in nemazee hospital. all pediatric patients (<18 years of age) who referred to our center with visible lower gi bleed­ing or two consecutive...