Small bowel bleeding should be considered in patients with overt or occult gastrointestinal hemorrhage after normal upper and lower endoscopic examination. Angiodysplasia appearing as multiple flat vascular tufts is the most common cause of small bowel bleeding in patients over 40 years old. Polypoid angiodysplasia, however, is extremely rare. This report illustrates a unique case of solitary p...

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract, while osseous metaplasia of this tumour is an unexpected event. To date, no cases have been reported in the literature. Herein, we report a case of a 60-year-old man affected by a GIST with benign osseous metaplasia and mature bone formation. We also discuss the pathogenesis of intra...

Gastrointestinal stromal tumors (GIST) are neoplasm of mesenchymal origin that usually begins in cells of the wall of the gastrointestinal tract. It can be benign or malignant. In this report, we have presented a case of malignant GIST with uncommon site of metastasis. This is of interest because of three reasons. Firstly, metastases to the testis are extremely rare. However, metastases to dist...

Gastrointestinal stromal tumors (GISTs) are rare, but are the most common mesenchymal neoplasm of the gastrointestinal tract. The most common sites of metastasis are liver and peritoneum, while bone metastasis is rare. We report on a patient with skull metastasis after seven years of treatment with imatinib for metastatic GIST. She underwent metastasectomy consisting of craniectomy with excisio...

Background: Gastrointestinal (GI) malignancies are the most common cancers and account for nearly half of all cancer-related deaths in Iran. There was a strong association between human papillomavirus (HPV) infection and urogenital cancers, in particular the cervix. However, there is no clear causal relationship in all types of cancers, including gastrointestinal cancers. Therefore, the present...

Intrahepatic and extrahepatic cholangiocarcinomas develops through a multistep carcinogenesis sequence and they are preceded by precursor lesions. Precursors of malignant neoplasm are identified in various organs including uterine cervix, gastrointestinal tract and breast. Identification of these precursor lesions are important in that they need minimal treatment or they are good indicator of d...

Abstract Peritoneum is a serosal membrane lining the solid viscera and hollow viscus of abdomen made single layer mesothelial cells. The most common primaries that spread to peritoneum include gastrointestinal, ovarian, colorectal, peritoneal metastases can be seen at some point during disease course in 15 43%, 60 70% 20% patients, respectively. Other malignancies involving such as primary carc...

Distant metastasis of gastrointestinal endocrine neoplasm is resistant to currently available treatments. Because hematogenic metastasis is dominant, anti-angiogenic drugs are expected to be a novel therapy for this neoplasm. In the present study, the therapeutic effect of vascular endothelial growth factor neutralizing antibody (VEGFAb) on liver metastasis of an endocrine neoplasm was investig...

Meckel’s diverticulum (MD) is commonest congenital gastrointestinal anomaly, the common complications associated with MD are hemorrhage, ulceration, intestinal obstruction, diverticulitis, umbilical anomalies, and neoplasm. Perforation of a rare entity there’s very less documentation regarding incidence perforation. perforation usually life-threatening complication high mortality, due to peptic...

Brunner's gland adenoma is an extremely rare benign small bowel neoplasm, often discovered incidentally during upper gastrointestinal endoscopy or radiological diagnostics. In few cases, it tends to cause gastrointestinal hemorrhage or intestinal obstruction. We report here our experience with a 47-year-old woman with a Brunner's gland adenoma of more than 6 cm in size, located in the first par...