Background: Probiotic potential (efficacy and safety) of Bacillus coagulans SNZ 1969 has been studied in patients with constipation-predominant irritable bowel syndrome (IBS-C) and-diarrhea predominant IBS (IBS-D).Methods: This randomized, double-blind, two-arm, placebo-controlled parallel study randomized 92 (1:1) to receive either 500 million CFU (treatment group) or placebo (placebo twice da...

OBJECTIVE Laparoscopic mesh-augmented hiatoplasty with cardiophrenicopexy (LMAH-C) might represent an alternative treatment of gastroesophageal reflux disease (GERD) and may provide durable reflux control without fundoplication. The expected benefit is the prevention of fundoplication-related side effects. Aim of the present trial was to compare LMAH-C with laparoscopic Nissen fundoplication (L...

OBJECTIVES Previous clinical trials have shown bowel function is improved through consumption of whole kiwifruit (Actinidia deliciosa). This study investigated whether encapsulated kiwifruit extract (1 g/day) could alleviate constipation in otherwise healthy adults. METHODS Forty adults with confirmed constipation entered this trial, of which 32 completed with >80% compliance. Two capsules we...

Aim. Evaluation of the effect polymorphisms CYP2D6, CYP2C8 genes on efficacy and safety postoperative analgesia with ketoprofen in patients coronary artery disease after cardiac surgery. Material methods . The study included 90 an established diagnosis period Patients received 100 mg intramuscularly 2 times a day for 5 days. intensity pain was rated by Numeric Rating Scale. severity dyspepsia a...

Abstract Objective Proximal gastrectomy acts as a function-preserving operation for upper-third gastric cancer. The aim of this study was to compare the short-term surgical outcomes between proximal with tube reconstruction and jejunal interposition in Methods A retrospective review 301 patients who underwent (JI) or (GT) at Harbin Medical University Cancer Hospital June 2007 December 2016 perf...

BACKGROUND Coeliac disease, an autoimmune disorder triggered by gluten ingestion, is managed by a gluten-free diet (GFD), which is difficult for many patients. Larazotide acetate is a first-in-class oral peptide that prevents tight junction opening, and may reduce gluten uptake and associated sequelae. AIM To evaluate the efficacy and tolerability of larazotide acetate during gluten challenge...

CONTEXT Since the advent of serologic testing for celiac disease, most persons who receive a diagnosis of celiac disease have few or no symptoms. Although pathologic changes of celiac disease resolve on a gluten-free diet, how a gluten-free diet affects the quality of life for patients with screen-detected celiac disease is unclear. OBJECTIVE To evaluate the effect of a gluten-free diet on th...

BACKGROUND To evaluate the efficacy and tolerability of a poly-herbal formulation, Herbagut, for the treatment of gastrointestinal symptoms and its effect on quality of life parameters in patients presenting with self-reported, unsatisfactory bowel habits. METHODS This was a randomised, double-blind, placebo-controlled trial. Fifty adults with self-reported unsatisfactory bowel habits, primar...

BACKGROUND Currently, a suitable questionnaire in German language is not available to monitor the progression and evaluate the severity of irritable bowel syndrome (IBS). Therefore, this study aimed to translate the Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome (GSRS-IBS) into German and to evaluate its psychometric qualities and factorial structure. METHODS This study is...