Viramontes, Blanca E., Allison Malcolm, Michael Camilleri, Lawrence A. Szarka, Sanna McKinzie, Duane D. Burton, and Alan R. Zinsmeister. Effects of an a2adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans. Am J Physiol Gastrointest Liver Physiol 281: G1468–G1476, 2001.—To characterize a2-adrenergic control of motor and sensory functions of gastrointestinal ...

Chloride channels modulate gastrointestinal neuromuscular functions in vitro. Lubiprostone, a selective type 2 chloride channel (ClC-2) activator, induces intestinal secretion and has been shown to relieve constipation in clinical trials; however, the effects of lubiprostone on gastric function and whole gut transit in humans are unclear. Our aim was to compare the effects of the selective ClC-...

Cisapride is known to accelerate gastrointestinal motility in various diseases with gastrointestinal motor abnormalities, and in normal subjects. In this study, we developed a new method to evaluate intestinal transit by radio-opaque markers, and evaluated the effect of oral doses of cisapride on intestinal transit in 6 normal subjects. Twenty markers were ingested with breakfast, and abdominal...

Where do all the tablets go in 1986? The surprising answer to this question is that our knowledge of the gastrointestinal transit of commonly prescribed drugs is remarkably patchy. As I will seek to show, however, techniques which allow a detailed description of the gastrointestinal transit, dispersion and dissolution of orally presented drugs now exist. Studies in this area are becoming increa...

1 Burgess DS. Pharmacodynamic principles of antimicrobial therapy in the prevention of resistance. Chest 1999; 115:19S– 23S 2 Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998; 26:1–12 3 Poen AC, Felt-Bersma RJF, Van Dogen PAM, et al. Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and an...

Description of Procedure or Service An ingestible pH and pressure-sensing capsule (SmartPill® GI Monitoring System) measures pH, pressure, and temperature changes to signify passage of the capsule through portions of the gastrointestinal tract. It is proposed as a means of evaluating gastric emptying for diagnosis of gastroparesis, and colonic transit times for the diagnosis of slow-transit con...

AIM To determine the contributions of gastrointestinal transit and pouch characteristics to bowel frequency in patients with an ileoanal reservoir and no pouchitis. METHODS Twenty one patients who had undergone restorative proctocolectomy, with ileostomy closure at least eight months previously, and who had no history of pouchitis were recruited. They were prospectively classified on the basi...

Gastrointestinal Tracking This cover shows a micro-computed tomography scan image of 3D-printed radiopaque microdevices with an arrow design providing X-ray traceability, as well potential improved gastrointestinal retention and transit, within oral drug delivery. work is found in article 2201897 by Tien-Jen Chang, Rolf Bech Kjeldsen, co-workers.