AIM To assess the appropriateness of gastroprotection in nonsteroidal anti-inflammatory drug (NSAID) users by primary care physicians. BACKGROUND A gastroprotective therapy is advised in NSAID users who are at a high risk for developing gastrointestinal side effects. However, an inappropriate (overuse/underuse) prescription of gastroprotection has been reported. STUDY This was a cross-secti...

Croton campestris A. St.-Hill., popularly known as "velame do campo," is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesio...

BACKGROUND AND PURPOSE Clinical guidelines recommend the prescribing of gastroprotective strategies in nonsteroidal anti-inflammatory drug (NSAID) users with risk factors for gastrointestinal (GI) ulcer or ulcer complications. However, these guidelines are not often translated into clinical practice. Therefore, the aim of this study was to investigate the utilization of gastroprotective strateg...

Several plants are used in folk medicine to treat gastrointestinal disorders. Ananas ananassoides (Baker) L.B. Smith (Family Bromeliaceae) is a medicinal plant commonly used in the central region of Brazil against gastric pain. We evaluated two extracts (methanol [MeOH] and dichloromethane [DCM]) obtained from the leaves of A. ananassoides for their ability to protect the gastric mucosa against...

Background: The last decade has been marked by increasing data regarding gastroinstestinal diseases, specially gastritis and ulcer. In order to prevent or treat these diseases, many studies have demonstrated the potential of medicinal plants. The aim of this study was to evaluate the phytochemical profile and the gastroprotective activity of the methanolic extract of Myrcianthes pungens whole f...

Agmatine (decarboxylated arginine) exerts cytoprotective action in several tissues, such as in the brain, heart or kidneys, but there is still controversy over the effects of agmatine on the gastric mucosa. The aim of the present study was to reveal the potential gastroprotective action of agmatine by using an acid-independent ulcer model to clarify which receptors and peripheral factors are in...

Gyires, K., Ronai, A.Z., Mullner, K., Fehér, E. (1998) Central components ingastroprotection. Zeitschrift für Gastroenterologie 36/5: p424 Mullner, K., Skoura, I. C., Gyires, K., Ronai A.Z. (1999) Analysis of the central cyto-protective and antisecretory effects of the alpha2 adrenoceptor agonist cloni-dine Dolor Vol. 14: Suppl.1., p54 Gyires, K., Mullner, K., Ronai, A.Z. (1999) Cen...

Gastric ischemic preconditioning is one of the most effective approaches to attenuate the gastric mucosal injury caused by severe ischemia-reperfusion. In the present study we investigated whether glucocorticoid hormones participate in a realization of gastroprotective effect of ischemic preconditioning. Rats were exposed to prolonged gastric ischemia-reperfusion (30 min occlusion of celiac art...

s 1. Gyires, K., Ronai, A.Z., Mullner, K., Fehér, E. (1998) Central components in gastroprotection. Zeitschrift für Gastroenterologie 36/5: p424 2. Mullner, K., Skoura, I. C., Gyires, K., Ronai A.Z. (1999) Analysis of the central cytoprotective and antisecretory effects of the alpha-2 adrenoceptor agonist clonidine Dolor Vol. 14: Suppl.1., p54 3. Gyires, K., Mullner, K., Ronai, A.Z. (1999) Cent...

BACKGROUND Syngonanthus arthrotrichus and Syngonanthus bisulcatus, currently known for Comanthera aciphylla (Bong.) L.R.Parra & Giul. and Comanthera bisulcata (Koern.) L.R. Parra & Giul, popularly known in Brazil as "sempre-vivas," are plants from the family Eriocaulaceae. They are found in the states of Minas Gerais and Bahia. The species are known to be rich in flavonoids to which their gastr...