This paper considers the problem of placing a single rectangular generalized congested region (GCR) of given area but unknown dimensions in the presence of other rectangular GCRs, where the edges of the rectangles are parallel to the travel axes. GCRs are closed and bounded regions in 2 in which facility location is prohibited but travel through is allowed at an additional cost per unit distanc...

We address the problem of two pairs of fermions living on an arbitrary number of single particle levels of a potential well (mean field) and interacting through a pairing force in the framework of the Richardson’s equations. The associated solutions are classified in terms of a number vl, which reduces to the seniority v in the limit of a large pairing strength G and yields the number of pairs ...

The abundance of Li, Be, and B isotopes in galactic cosmic rays (GCR) between E=50-200 MeV/nucleon has been observed by the Cosmic Ray Isotope Spectrometer (CRIS) on NASA’s ACE mission since 1997 with high statistical accuracy. Precise observations of Li, Be, B can be used to constrain GCR propagation models. We find that a diffusive reacceleration model with parameters that best match CRIS res...

We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studies. In study 1, we assessed stressful life events, GCR, and control variables including baseline antibody to the challenge virus, age, body mass index (BMI), season, race, sex, e...

The heliospheric modulation strength is a good parameter for the long-term modulation of cosmic rays in the neutron monitor energy range. Here we study an empirical relation between the modulation strength and the global heliospheric parameters: the heliospheric current sheet tilt angle, the open solar magnetic flux and the global IMF polarity. The suggested relation closely reproduces the meas...

BACKGROUND Visceral fat deposition and its associated atherogenic complications are mediated by glucocorticoids. Cardiac visceral fat comprises mediastinal adipose tissue (MAT) and epicardial adipose tissue (EAT), and MAT is a potential biomarker of risk for obese patients. AIM Our objective was to evaluate the role of EAT and MAT 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and glu...

The effect of the Galactic Cosmic Ray (GCR) flux on Earth’s climate is highly uncertain. Using a novel sampling approach based around observing periods of significant cloud changes, a statistically robust relationship is identified between short-term GCR flux changes and the most rapid mid-latitude (60–30 N/S) cloud decreases operating over daily timescales; this signal is verified in surface l...

The intensity of cosmic rays in the inner solar system is observed to vary with time over a variety of time scales. The Sun is the cause of some of these variations, but the observed longer-term variations reflect changes in the local interstellar medium. Galactic cosmic rays (GCR) dominate the average intensity of energetic particles above about 200 MeV and are affected by supernova shock wave...

BACKGROUND Compared to children, adult patients with minimal change disease (MCD) tend to have a slower response to steroids, but little is known about the factors influencing the steroid responsiveness in these patients. In this study, we investigated the difference in the expression of the glomerular glucocorticoid receptor (GCR) according to steroid responsiveness in 28 adult-onset MCD patie...

Mustafa, Shamimunisa B., Robert J. DiGeronimo, Jean A. Petershack, Joseph L. Alcorn, and Steven R. Seidner. Postnatal glucocorticoids induce -ENaC formation and regulate glucocorticoid receptors in the preterm rabbit lung. Am J Physiol Lung Cell Mol Physiol 286: L73–L80, 2004. First published August 29, 2003; 10.1152/ajplung.00342.2002.—At birth, lung fluid clearance is coupled to Na transport ...