Introduction Asian prostate cancer (PC) patients are particularly susceptible to docetaxel-related febrile neutropenia (FN). We evaluated primary granulocyte colony-stimulating factor (GCSF) for preventing FN in Chinese with metastatic hormone-sensitive PC (mHSPC) and castration-resistant (mCRPC). Patients methods Data from two cohorts of 377 mHSPC (100; 26.5%) mCRPC (277; 73.5%) treated doceta...

Granulocyte colony-stimulating factor (G-CSF)-producing nonhematopoietic malignancies have been reported in various organs and are associated with a poor clinical outcome. Moreover, carcinoma of unknown primary site (CUP) is an uncommon malignancy that occurs in about 2-6% of cancer patients. CUP also has a poor prognosis due to its missing profile. Since both G-CSF-producing carcinoma and CUP ...

The present study was aimed to evaluate the incidences of chemotherapy-induced neutropenia in patients with solid tumors in India. The patients with carcinomas of breast, lung, ovary, colon, head and neck, and liver were divided in two groups. Group 1 was for the patients who experienced grade 0-2 neutropenia and Group 2 was for patients with grade 3-4 neutropenia. Different types of chemothera...

The objective of this study was to determine if the inverse relationship between perceived physical fitness (pFIT) and exercise frequency (ExFreq) levels and chronic inflammation and oxidative stress exists after making statistical adjustments for confounders including body mass index (BMI), age, gender, and cigarette smoking. Study participants (60% female and 40% male; n = 998) varied widely ...

PEGylation of therapeutic proteins has signifi cantly improved their value by altering the physicochemical and biological properties such as increased solubility, decreased immunogenicity, increased half-life, and protection against proteases. Size Exclusion Chromatography (SEC) is the method of choice for determining impurities with molecular mass higher than that of PEGylated proteins. SEC of...

A fibroblast-mediated gene delivery method was used for the endogenous expression of human granulocyte colony-stimulating factor (G-CSF) as a model for cytokine supplement therapy. Human G-CSF cDNA was inserted into the plasmid expression vector BMGNeo, which contains a partial sequence of bovine papilloma virus and a selectable marker gene. The recombinant plasmid (BMGNeo-GCSF) was transfected...