Antigen recognition by B and T lymphocytes is achieved by highly diverse heterodimeric receptors, the Band T-cell receptors (TCRs). T lymphocytes can be subdivided into two mutually exclusive subpopulations carrying TCR chains encoded by either a and b or g and d gene loci. These T-cell subsets are classically referred to as ‘ab’ and ‘gd’ T cells, respectively. Like other antigen receptors, the...

Urinary diluting ability and protein abundance of renal aquaporins (AQPs) and ion transporters in glucocorticoid-deficient (GD) rats were examined at baseline and in response to oral water loading. Rats underwent bilateral adrenalectomy followed by aldosterone (GD) or aldosterone + dexamethasone (CTL) replacement. Before oral water loading, urinary output was significantly decreased and urinary...

[1] We measured the phonon density of states (DOS) of hexagonal close‐packed iron ("‐Fe) with high statistical quality using nuclear resonant inelastic X‐ray scattering and in situ X‐ray diffraction experiments between pressures of 30 GPa and 171 GPa and at 300 K, with a neon pressure medium up to 69 GPa. The shape of the phonon DOS remained similar at all compression points, while the maximum ...

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Background: The monoclonal antibody, C595, against breast cancer cell line was conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (Gd-cDTPAa) to produce Gd-DTPA-C595 and used as specific breast cancer cell line (MCF-7) contrast agents in magnetic resonance imaging (MRI).  Methods: After incubation of breast cancer cell line (MCF-7), with different contrast agents (G...

We previously defined eight groups of monoclonal antibodies which react with distinct epitopes of herpes simplex virus glycoprotein D (gD). One of these, group VII antibody, was shown to react with a type-common continuous epitope within residues 11 to 19 of the mature glycoprotein (residues 36 to 44 of the predicted sequence of gD). In the current investigation, we have localized the sites of ...

Valproic acid (VPA) has been used clinically as an anticonvulsant medication during pregnancy; however, it poses a neurodevelopmental risk due to its high teratogenicity. We hypothesized that midgestational (GD) exposure to VPA will lead to lasting deficits in social behavior and the processing of social stimuli. To test this, animals were given a single IP injection of 600 mg/kg of VPA on GD 1...

background: the monoclonal antibody, c595, against breast cancer cell line was conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (gd-cdtpaa) to produce gd-dtpa-c595 and used as specific breast cancer cell line (mcf-7) contrast agents in magnetic resonance imaging (mri).  methods: after incubation of breast cancer cell line (mcf-7), with different contrast agents (g...

Given a combinatorial designD with block set B, its traditional block-intersection graph GD is the graph having vertex set B such that two vertices b1 and b2 are adjacent if and only if b1 and b2 have non-empty intersection. In this paper we consider the S-block-intersection graph, in which two vertices b1 and b2 are adjacent if and only if |b1 ∩ b2| ∈ S. As our main result we prove that {1, 2,...

The idea of metric dimension in graph theory was introduced by P J Slater in [2]. It has been found applications in optimization, navigation, network theory, image processing, pattern recognition etc. Several other authors have studied metric dimension of various standard graphs. In this paper we introduce a real valued function called generalized metric + → × × R X X X Gd : where = = ) / ( W v...