Poly(N-isopropyl acrylamide) (pNIPAM) is one of the most popular stimulus-responsive polymers for research. It is especially of great interest in the field of tissue engineering. While it is known that the NIPAM monomer is toxic, there is little conclusive research on the cytotoxicity of the polymer. In this work, the relative biocompatibility of the NIPAM monomer, pNIPAM, and pNIPAM-coated sub...

Radiation dosimetry by Fricke gel was largely used, generally focused and optimized for radiotherapy applications therefore involving relative high dose levels. Fricke gel dosimetry has several advantages, like dose rate and LET almost independence, 3D mapping, among other. This work presents a novel Fricke gel dosimeter optimized for low dose levels. Several chemical composition were studied v...

Introduction: Computed tomography (CT) has numerous applications in clinical procedures but its main problem is its high radiation dose to the patients compared to other imaging modalities using x-ray. CT delivers approximately high doses to the nearby tissues due to the scattering effect, fan beam (beam divergence) and limited collimator efficiency. The radiation dose from multi-slice scanners...

Copolymerization of N-isopropylacrylamide (NIPAM), itaconamic acid (IAM; 4-amino-2-methylene-4-oxobutanoic acid) and β-cyclodextrin was investigated in this study. β-cyclodextrin was at first modified by reacting with allyl glycidyl ether to substitute its OH end groups with moieties containing double bonds to facilitate the subsequent radical copolymerization with NIPAM and IAM. It was reporte...

Spectrophotometric measurements of the Fricke–gelatin–xylenol orange (FGX) gel dosimeter demonstrated reproducible linear dose response up to 25Gy. However, oxidation processes continue post-irradiation, affecting the response of this dosimetry system. Additional oxygenation during preparation increases the sensitivity of the gel but does not improve the auto-oxidation stability of the dosimete...

Poly (N-isopropylacrylamide-acrylic acid) [p(NIPAM-AAc)] microgel was successfully fabricated using the precipitation polymerization method. Silver (Ag) nanoparticles and graphene oxide (G) were used to fabricate following hybrid microgels: Ag-p(NIPAM-AAc) (Ag-HMG), Ag-G-p(NIPAM-AAc) (Ag-G-HMG), G-p(NIPAM-AAc) (G-HMG). Ag-HMG, Ag-G-HMG, G-HMG characterized a Zetasizer UV-Vis spectroscopy. The r...

In this work gold nanoparticles (AuNP) were embedded in MAGIC-f gel and irradiated in a 250 kV x-ray clinical beam. The signal of non-irradiated gel samples containing AuNPs showed maximum difference of 0.5% related to gel without nanoparticles. Different AuNPs concentrations were studied: 0.10 mM, 0.05 mM and 0.02 mM, presenting dose enhancements of 106%, 90% and 77% respectively. Monte Carlo ...

abstractbackground: polymer gels are an emerging new class of dosimeters which are being applied to the challenges of modern radiotherapy modalities. research on gel dosimetry involves several scientific domains, one of which is the imaging techniques with which dose data is extracted from the dosimeters. in the current work, we present our preliminary results of investigating capability of x-r...

introduction: despite the fact that the clinical implementation of polymer gel dosimetry has been facilitated after the introduction of normoxic gels, there are still complications in its clinical routine use that are under investigation. in the current work, the feasibility of using a normoxic polymer gel dosimeter named magica has been investigated for use in our clinical brachytherapy applic...