The present paper focuses on solid lipid particles (SLPs), described in the literature as the most effective lipid drug delivery systems that have been introduced in the last decades, as they actually combine the advantages of polymeric particles, hydrophilic/lipophilic emulsions and liposomes. In the current study, we present our most recent advances in the preparation of alendronate (AL)-load...

Ophthalmic drops for ocular delivery exhibit inadequate residence time, which often requires multiple daily dosing that may result in patient non-adherence. In this study, the development of a once-daily-dosed chitosan-coated metronidazole (MTZ)-loaded solid lipid nanoparticles (SLNs) was undertaken. Melt emulsification and ultrasonication were used to manufacture MTZ-loaded SLN, subsequently c...

Objective: The aim of this investigation was to enhance the solubility and bioavailability BCS class II poorly water-soluble drug ambrisentan by solid dispersion (SD) techniques using Gelucire 50/13 as a hydrophilic carrier. Methods: Solid prepared kneading method different dug: carrier ratios. Prepared SD characterized for solubility, content, percentage yield, in vitro dissolution, ex vivo pe...

Etravirine is an antiviral belonging to biopharmaceutics classification system class IV due low aqueous solubility and poor permeability. In this study, augment the dissolution profile of etravirine, solid lipid nanoparticles have been formulated by utilizing mixture Compritol® 888 ATO Gelucire® 50/13 as lipids poloxamer 188 surfactant hot homogenization technique. Effect variables, ratio lipid...

It had became a challenging experience and effort for formulator to develop innovate drug with maximum bioavailability. In the present study focus of research is in treatment Hypertension, which one most prevalent cardiovascular diseases world, affecting big proportion adult old age population. Candesartan Cilexetil angiotensin II AT1 many tissues including vascular smooth muscle adrenal glands...

In this study, a gelatin microparticle-containing self-microemulsifying formulation (SMF) was developed using a spray-drying method to enhance the oral delivery of the poorly water-soluble therapeutic dutasteride. The effect of the amount of gelatin and the type and amount of hydrophilic additives, namely, Gelucire(®) 44/14, poloxamer 407, sodium lauryl sulfate, Soluplus(®), Solutol™ HS15, and ...

Poor bioavailability of Docetaxel (DCT) arising due to its low aqueous solubility and permeability limits its clinical utility. The aim of the present study was to develop DCT loaded self-emulsified drug delivery systems (D-SEDDS) and evaluate its potential ability to improve the oral bioavailability and therapeutic efficacy of DCT. D-SEDDS were characterized for their in vitro antitumor activi...