Objective: This study aimed to identify potential risk genes and microRNAs (miRNAs) related to the recurrence risk of osteosarcoma (OS) using support vector machine (SVM) algorithm. Methods: Based on the mRNA expression profiling dataset GSE39055 and the miRNA expression profiling dataset GSE39040, differentially expressed genes (DEGs) and differentially expressed miRNAs (DE-miRNAs) indiagnosti...

suicide is a major public health concern, with approximately one million people committing suicide world-wide each year .risk factors for suicidal behavior include, psychiatric and medical illness, impulsivity, aggression, alcohol and drug abuse specially stimulants, and  stress. neurobiological, brain mappings and biochemical studies have revealed that suicide victims experiencing a large numb...

Gene therapy offers important perspectives in current and future medicine but suffers from imperfect vectors for the delivery of the therapeutic gene. Most preclinical and clinical trials have been based on the use of viral vectors, which have evident advantages but also some serious disadvantages. In the past decade the use of DNA transposon-based systems for gene delivery has emerged as a non...

The transition from normal forage to a highly fermentable diet to achieve rapid weight gain in the cattle industry can induce ruminal acidosis. The molecular host mechanisms that occur in acidosis are largely unknown. Therefore, the histology and transcriptome profiling of rumen epithelium was investigated in normal and acidosis animals to understand the molecular mechanisms involved in the dis...

Differentially expressed genes between corresponding normal and cancertissue can advance our understanding of the molecular basis of malignancy and potentially serve as biomarkers or prognostic markers of malignancy. To identify differentially expressed genes in prostate cancer, we used a procedure combining electronic expression profiling of the prostate expressed sequence tag (EST) database a...

abiotic stress are the main factors causing low growth and yield in crops. osmotic stress is an important stress and in case of salinity stress is presuming at the first step. there are different experimental and computational methods to study plant response to stress and lead to better understanding of mechanism involved in these conditions and improvement of plant tolerance to stress. upstrea...

Information on population age structure of mosquitoes under natural conditions is fundamental to the understanding of vectorial capacity and crucial for assessing the impact of vector control measures on malaria transmission. Transcriptional profiling has been proposed as a method for predicting mosquito age for Aedes and Anopheles mosquitoes, however, whether this new method is adequate for na...

BACKGROUND Previous transcriptome profiling studies have investigated the molecular mechanisms of pollen and anther development, and identified many genes involved in these processes. However, only 51 anther ESTs of Upland cotton (Gossypium hirsutum) were found in NCBI and there have been no reports of transcriptome profiling analyzing anther development in Upland cotton, a major fiber crop in ...

results comparative analysis of predicted amino acids in the phylogenetic tree showed high similarity between c. glabrata and s cerevisiae. besides, c. glabrata demonstrated the capability to grow in glucose levels as low as 0.01% in the spot dilution assay. in qrt-pcr analysis, differential expressions were observed in selected genes when c. glabrata was subjected to different glucose concentr...

Abstract Measured spectral shifts due to intrinsic stellar variability (e.g., pulsations, granulation) and activity spots, plages) are the largest source of error for extreme-precision radial-velocity (EPRV) exoplanet detection. Several methods designed disentangle signals from true center-of-mass planets. The Extreme-precision Spectrograph (EXPRES) Stellar Signals Project (ESSP) presents a sel...