G TPases of the Rab family, which comprises more than 60 members in mammals, have emerged as key regulators of virtually all transport steps between intracellular compartments. By interacting with a diverse range of effector proteins, such as lipid kinases and phosphatases, molecular motors, tethering factors, and scaffolding proteins, they regulate the formation of transport carriers from dono...

microcerotermes diversus (silvestri) (isoptera: termitidae), an important wood pest in ahwaz (khuzestan, iran), causes serious economic damage to cellulosic products in buildings. to investigate the genetic diversity of this pest, 13 populations from different areas of khuzestan province as well as two samples from khark island and bandar abbas were collected. following dna extraction a fragmen...

The Rho GDP dissociation inhibitor (GDI) forms a complex with the GDP-bound form of the Rho family small G proteins and inhibits their activation. The GDP-bound form complexed with Rho GDI is not activated by the GDP/GTP exchange factor for the Rho family members, suggesting the presence of another factor necessary for this activation. We have reported that the Rho subfamily members regulate th...

BACKGROUND This article is based upon data gathered during a study conducted in partnership with the World Intellectual Property Organization on the patent status of products appearing on the World Health Organization's 2013 Model List of Essential Medicines (MLEM). It is a statistical analysis aimed at answering: in which developing countries are patents on essential medicines being filed? M...

We characterized the role of guanine nucleotide dissociation inhibitor (GDI) in RhoA/Rho-kinase-mediated Ca2+ sensitization of smooth muscle. Endogenous contents (approximately 2-4 microM) of RhoA and RhoGDI were near stoichiometric, whereas a supraphysiological GDI concentration was required to relax Ca2+ sensitization of force by GTP and guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS). GDI al...

Different cytotoxic drugs induce cell death by activating the apoptotic programme; a family of cysteinyl aspartate proteases named caspases has been shown to be involved in the initiation as well as the execution of this kind of cell death. In the present study, cleavage of D4-GDI (Rho-GDI 2), an abundant haemopoietic-cell GDP dissociation inhibitor for the Ras-related Rho family GTPases, was d...

Adder cells using Gate Diffusion Technique (GDI) & PTL-GDI technique are described in this paper. GDI technique allows reducing power consumption, propagation delay and low PDP (power delay product) whereas Pass Transistor Logic (PTL) reduces the count of transistors used to make different logic gates, by eliminating redundant transistors. Performance comparison with various Hybrid Adder is bee...

D4-GDI is a key regulator of Rho GTPases that have been implicated in several aspects of breast tumorigenesis. We have previously found that D4-GDI was selectively expressed in breast cancer cell lines over normal mammary epithelial cells [45]. In this study, we investigated the expression level of D4-GDI in breast tumor specimens (n = 165) by immunohistochemistry using a validated antibody tha...

Guanine-nucleotide dissociation inhibitors (GDIs) are negative regulators of Rho family GTPases that sequester the GTPases away from the membrane. Here we ask how GDI-Cdc42 interaction regulates localized Cdc42 activation for cell motility. The sensitivity of cells to overexpression of Rho family pathway components led us to a new biosensor, GDI.Cdc42 FLARE, in which Cdc42 is modified with a fl...