Background Cancer cells reprogram their metabolism for optimal growth and survival. Identifying the genes and their functions crucial for cancer metabolic reprograming might have therapeutic implications. The multifunctional kinase AMPK is an evolutionarily conserved energy sensor that plays an important role in cell proliferation, growth and survival. It remains unclear whether AMPK functions ...

Movement is an important life history trait that can have an impact on local adaptation, and other evolutionary phenomena. We used a combination of nestbox survey data and genetic techniques (genotyping at 10 microsatellite loci) to quantify patterns of movement in common dormice Muscardinus avellanarius at two distinct sites in the UK: 1) Bontuchel (a natural population) and 2) Wych (captive-b...

The development of specialized application accelerators is happening today. However, they do not share a common attach point, and have no common architecture or programing model. A framework that economically and efficiently enables specialized acceleration is highly desirable. In this work we propose a generic interface concept called ”ACCFS” for integrating application accelerators into Linux...

UNLABELLED The identification and exploration of moderators of health department accreditation remain limited by current dichotomous conceptualizations of pursuit. METHODS A 2015 survey measured Indiana local health department (LHD) accreditation pursuit and progress, classifying respondents by progress evidence. Covariates included attitudes about the future impact of accreditation on fundin...

Optimization has become an important tool in treatment planning for cancer radiation therapy. It may be used to determine beam weights, beam directions, and appropriate use of beam modifiers such as wedges and blocks, with the aim of delivering a required dose to the tumor, while sparing nearby critical structures and normal tissue. Linear programing formulations are a core computation in many ...

Improvements in distributed computing, and the technologies that enable them, have led to significant advancements in middleware functionality and quality, mainly through networking and protocols. However, the distributed programing style has changed little over the years. Most programs are still written line per line of code in languages such as C, Cþþ, and Java. These conventional programs th...