The differences are reported in the triacylglycerol (TG) structures of oils containing gamma-linolenic acid (GLA) from Oenothera biennis Linn seed oil (OBLO) from the wild plant, evening primrose seed oil (EPO) from a cultured plant, and bio-GLA oil (BIO) from a mold, the physiological functions of which were ascertained by animal testing. Reverse-phase high-performance liquid chromatographic s...

Randomized participants (n = 811) had amean (SD) HbA1c of 8.24% (0.82) and BMI of 34.8 kg/m (6.4). Glycemic control improved similarly with both basal insulins; least squares mean (SD) reduction from baseline was 20.57% (0.09) for Gla-300 and20.56% (0.09) for Gla-100 (mean difference20.01% [95% CI20.14 to 0.12]), with 10% higher dose of Gla-300. Less nocturnal confirmed (£3.9 mmol/L [£70 mg/dL]...

The interaction of human adenovirus (HAdV)-C5 and many other adenoviruses with blood coagulation factors (e.g., human factor X, FX) involves the binding of their GLA domain to the hexon capsomers, resulting in high levels of hepatotropism and potential hepatotoxicity. In this study, we tested the possibility of preventing these undesirable effects by using a GLA-mimicking peptide as a competito...

Introduction Gamma-linolenic acid (GLA) is an important conditionally essential fatty acid (EFA). GLA is an omega-6 polyunsaturated fatty acid (PUFA). The fatty acid molecule is comprised of 18 carbon atoms with three double bonds. It is also known as 18:3n-6; 6,9,12-octadecatrienoic acid; cis-6, cis-9, cis-12octadecatrienoic acid; and gamolenic acid. GLA is found naturally in the fatty acid fr...

INTRODUCTION Atopic dermatitis (AD) has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) contains high amounts of GLA. Therefore, this study investigated whether EPO supplementation results in an increase in plasma GLA and its metabolite dihomo-gamma-linolenic acid (DGLA) corre...

AIMS To evaluate the effect of concomitant dipeptidyl peptidase IV inhibitor (DPPIVi) use on efficacy and safety of insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100) in people with type 2 diabetes on oral antihyperglycaemic drugs. METHODS A post hoc patient-level meta-analysis was performed using data from EDITION 2 (basal insulin [N = 811]) and EDITION 3 (insulin-naïve [...

Objective. To compare pharmacokinetics and -dynamics (PD) of insulin glargine (GLA) and detemir (DET), 24 subjects with T1DM (38±10 years, BMI 22.4±1.6, kg/m, HbA1c 7.2±0.7%, mean±SD) were studied after 2 week treatment with either GLA or DET once daily (randomized, double-blind, cross-over study). Methods. Plasma glucose (PG) was clamped at 100 mg/dl for 24-h after s.c. injection of 0.35 U/kg....

In this post hoc analysis we compared glycaemic control and hypoglycaemia between insulin glargine 300 U/mL (Gla-300) and glargine 100 U/mL (Gla-100) administered once daily in people with type 2 diabetes (T2DM) from the EDITION 1 (basal plus mealtime insulin) and EDITION 2 (basal insulin plus oral antihyperglycaemic drugs) trials who were previously receiving twice-daily insulin. At randomizat...

A glucoamylase::green fluorescent protein fusion (GLA::sGFP) was constructed which allows the green fluorescent protein to be used as an in vivo reporter of protein secretion in Aspergillus niger. Two secretory fusions were designed for secretion of GLA::sGFP which employed slightly different lengths of the glucoamylase protein (GLA499 and GLA514). Expression of GLA::sGFP revealed that fluoresc...

The effects of chronic treatments of adult (aged 16-17 weeks) spontaneously hypertensive rats (SHRs) with different doses of y-linolenic acid (GLA) on blood pressure, heart rate, and body weight were studied. Twice-daily injection of SHRs with GLA lowered systolic blood pressure from 175±4 to 145±4 mm Hg within 1 week; systolic blood pressure in all three treated groups became stabilized in the...