Liu, Yan, Shigetoshi Oiki, Takehiko Tsumura, Takahiro Shimizu, and Yasunobu Okada. Glibenclamide blocks volume-sensitive Cl2 channels by dual mechanisms. Am. J. Physiol. 275 (Cell Physiol. 44): C343–C351, 1998.—To study the mechanisms of glibenclamide actions on volume-sensitive Cl2 channels, whole cell patch-clamp studies were performed at various pH levels in human epithelial Intestine 407 ce...

Aims:To clarify differences in insulin-secretagogue and antihyperglycemic properties between glimepiride and glibenclamide. Methods:Catheters were inserted into the portal veins of 12-week-old,obese,spontaneously type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats and left in place.After 17-hour fasting, the rats were given either 1 mg/kg of glibenclamide,1 mg/kg of glimepiride,or 0.5% methy...

BACKGROUND The aim of the present study was to investigate the effect of ginger and glibenclamide on oxidative stress markers. Oxidative stress is caused by an unbalance between a relative overload of oxidants and depletion of antioxidants, as implicated in the pathogenesis of several chronic diseases, including atherosclerosis and diabetes mellitus. Regarding the role of oxidative stress in th...

Insulin, Glibenclamide and Tolbutamide are some of the frequently used drugs for the most common metabolic disorders, diabetes mellitus. Along with hypoglycaemic drugs diabetic patient is exposed to variety of drugs. NSAIDs are one of the commonly used drugs in this metabolic syndrome. When a patient on hypoglycaemic drugs receives NSAIDs there are chances of drug interactions. This study was u...

Background: Diabetes is an important risk factor for cardiovascular events. Endothelial dysfunction is the main reason cause of disability and death in diabetic patients and death. The present study investigates the effects of metformin and glibenclamide on vasoconstrictive and vasodilative responses in the diabetic rat aorta. Methods: Rats were divided into four experimental groups (con...

In this study, as an approach to possible pharmacokinetic interactions between antidiabetic agents and health foods, we investigated the binding of metformin and glibenclamide to aojiru, kurosu, and blueberry extract using a dialysis method. The permeation of metformin from the inner to the outer side of the dialysis tube during 90 min was not altered in the presence of aojiru or kurosu, and sl...

OBJECTIVE To examine the effects of glibenclamide treatment on plasma lipids and lipoprotein levels. SETTINGS Out patients of Type II diabetics from department of Baqai Diabetes and Endocrine Centre and two other diabetic clinics of Karachi. METHODS The effects of glibenclamide on blood glucose and various aspects of lipoproteins has been studied in 26 (14 male, 12 female) Type II Diapetes ...

We tested the hypothesis that ATP-sensitive K+ channels are involved in the mechanism mediating coronary autoregulation in open-chest dogs. We perfused the left anterior descending coronary artery with arterial blood from an extracorporeal circuit and measured steady-state coronary blood flow (CBF) with stepwise changes in coronary perfusion pressure (CPP) between 50 and 150 mm Hg during an int...

Type 2 diabetes affects 100 million people throughout the world. Among the various factors implicated in the causation of this disease, the role of leptin, an obesity gene product, is increasingly being investigated. This especially assumes importance in the light of knowledge that obesity confers a minimum of 3-10 fold higher risk of diabetes. This study was planned to investigate the relation...