It was previously demonstrated that avirulent Mycoplasma gallisepticum strain R(high) (passage 164) is lacking three proteins that are expressed in its virulent progenitor, strain R(low) (passage 15). These proteins were identified as the cytadhesin molecule GapA, the putative cytadhesin-related molecule CrmA, and a component of a high-affinity transporter system, HatA. Complementation of R(hig...

We have recently developed a Corynebacterium glutamicum strain that generates NADPH via the glycolytic pathway by replacing endogenous NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GapA) with a nonphosphorylating NADP-dependent glyceraldehyde 3-phosphate dehydrogenase (GapN) from Streptococcus mutans. Strain RE2, a suppressor mutant spontaneously isolated for its improved growth on gl...

The Gram-positive bacterium Staphylococcus aureus contains two glyceraldehyde-3-phosphate dehydrogenase (GAPDH) homologues known as GapA and GapB. GapA has been characterized as a functional GAPDH protein, but currently there is no biological evidence for the role of GapB in metabolism in S. aureus. In this study we show through a number of complementary methods that S. aureus GapA is essential...

BACKGROUND Whereas taxation on alcohol is becoming an increasingly common practice in many countries as part of overall public health measures, the Hong Kong Special Administrative Region Government is bucking the trend and lowered its duties on wine and beer by 50 percent in 2007. In 2008, Hong Kong removed all duties on alcohol except for spirits. The aim of this paper is to examine the case ...

Aspergillus nidulans gapA1, a mutation leading to compact, fluffy colonies and delayed polarity establishment, maps to a gene encoding a Ras GTPase-activating protein. Domain organization and phylogenetic analyses strongly indicate that GapA regulates one or more "true" Ras proteins. A gapADelta strain is viable. gapA colonies are more compact than gapA1 colonies and show reduced conidiation. g...

To remain competitive in this global and technological world, academic institutions and corporations worldwide need to take serious steps to created a diverse, well-trained and multicultural workforce. To this end, the Global Alliance in Science and Engineering for Diversifiing the Worvorce was created to offer an opportunity to share best practices in education, industry, government and profes...

A t the World Health Assembly in May 2003, three civil society groups—the People's Health Movement, the Global Equity Gauge Alliance, and Medact—discussed the need for civil society to produce its own alternative to the World Health Organisation's World Health Report. We felt strongly that we needed to produce a global health report that had equity and the right to health at its heart. We also ...

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I n November 2003 an international meeting of major importance took place in London on the theme of patient safety. Policy makers, clinical leaders, and experts from many countries around the world came together to consider the next steps in making resolution WHA 55.18 passed by the World Health Assembly in May 2002 an operational reality. The original resolution urged countries to pay the grea...

WHO is honored to cosponsor this important event together with the Ministry of Health of Brazil, ILA and ILEP. We are especially grateful to Government of Brazil and members of the Organizing Committee for planning and organizing the Congress. This is the second important meeting which the Brazilian authorities have kindly hosted this year the first being the meeting of the Global Alliance for ...