نتایج جستجو برای: glomerular basement membrane
تعداد نتایج: 417463 فیلتر نتایج به سال:
A case of mixed membranous and proliferative glomerulonephritis has been studied by light and electron microscopy. Electron microscopy has shown that the cellular proliferation is mesangial in origin and that there are qualitative and quantitative alterations in the filtration basement membrane. In addition there are numerous examples of direct contact between filtration basement membrane and n...
Heparan sulfate in the glomerular basement membrane has been considered crucial for charge-selective filtration. In many proteinuric diseases, increased glomerular expression of heparanase is associated with decreased heparan sulfate. Here, we used mice overexpressing heparanase and evaluated the expression of different heparan sulfate domains in the kidney and other tissues measured with anti-...
We investigated nephritogenic potential of antibodies to heparan sulfate-proteoglycan of glomerular basement membrane. Glomeruli were isolated, basement membranes were prepared, proteoglycans extracted, and purified core protein was obtained. We immunized rabbits with the core protein, IgG fraction prepared from the antisera and specificity of the antibody determined. A single immunoprecipitin ...
Staining reactions characteristic of collagen and reticulin are found in pathologically altered glomeruli (1, 2), and fibrils with the periodicity of collagen fibrils have been observed occasionally in electron micrographs of severely damaged glomerular tufts. However, as far as we are aware, fibrils have not been found by light or electron microscopy in the normal glomerular tuft, except at th...
Conclusion It would appear then, that both GBM and the renal parenchyma as a whole contain diverse charged components. Abnormalities of GBM anionic charge expression are more complex than at first conceived, reflecting often subtle alterations in membrane matrix charged structures which may have a minimal or profound, direct or indirect influence on membrane permeability. The original concept o...
Elastase is an elastin lytic enzyme that inhibits the deposition of fat on arterial walls and suppresses fat buildup. The changes in the renal glomerular basement membrane were observed over 30days ofelastase administration in N. Y. S. mice (experimental congenital diabetic animals). and the treated group showed a lessening in the thickening of the basement membrane. The thichness of the baseme...
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