نتایج جستجو برای: glu298asp polymorphism

تعداد نتایج: 107378  

Journal: :Diabetes care 2004
Takuya Awata Tamotsu Neda Hiroyuki Iizuka Susumu Kurihara Tomoko Ohkubo Nobuki Takata Masataka Osaki Masaki Watanabe Youhei Nakashima Takahiro Sawa Kouichi Inukai Ikuo Inoue Masayuki Shibuya Keisuke Mori Shin Yoneya Shigehiro Katayama

OBJECTIVE We examined the endothelial nitric oxide (eNOS) gene polymorphisms to assess its possible association with diabetic retinopathy and macular edema. RESEARCH DESIGN AND METHODS A total of 226 patients with type 2 diabetes and 186 healthy subjects were studied. Type 2 diabetic patients consisted of 110 patients without retinopathy, 46 patients with nonproliferative diabetic retinopathy...

Journal: :The Indian journal of medical research 2009
N S Nishevitha T Angeline Nirmala Jeyaraj

BACKGROUND & OBJECTIVE Nitric oxide (NO) synthesized by endothelial cells is known to be a potent vasodilator. It has been suggested that the single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (eNOS) (G894T) may affect the response of vascular endothelium to increased oxidative stress. The Glu298Asp (GT) polymorphism located in exon 7, may be associated with several disea...

Journal: :Hypertension 2000
T Rankinen T Rice L Pérusse Y C Chagnon J Gagnon A S Leon J S Skinner J H Wilmore D C Rao C Bouchard

Endothelium-dependent vasodilation is a mechanism that may affect blood pressure response to endurance training. Because NO plays a central role in this process, the endothelial NO synthase gene is a good candidate for the regulation of exercise blood pressure. We investigated the associations between an endothelial NO synthase gene polymorphism (Glu298Asp) and endurance training-induced change...

2016
Rafael Amorim Belo Nunes Lucia Pereira Barroso Alexandre da Costa Pereira Maria Urbana Pinto Brandão Rondon Carlos Eduardo Negrão José Eduardo Krieger Alfredo José Mansur

PURPOSE Muscle vasodilatation during exercise has been associated with cardiovascular health and may be influenced by genetic variability. The purpose of this study was to evaluate functional genetic polymorphisms of physiologic pathways related to the regulation of the cardiovascular function (alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor) and exercis...

Journal: :Perm Medical Journal 2021

Objective. To study the polymorphisms of genes involved in angiogenesis and metabolic processes, to assess level lymphocytes patients with chronic endometritis practically healthy women reproductive period.
 Materials methods. 86 were examined; DNA regions eNOS 1799983 (Glu298Asp), PPARA (G2528C), ApoE rs429358 (Cys130Arg), MTHFR (C677T, A1298C) used as primers; blood (CD3+, CD4+, CD8+, CD...

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