Voltage-gated sodium channels (Navs) are glycoproteins composed of a pore-forming α-subunit and associated β-subunits that regulate Nav α-subunit plasma membrane density and biophysical properties. Glycosylation of the Nav α-subunit also directly affects Navs gating. β-subunits and glycosylation thus comodulate Nav α-subunit gating. We hypothesized that β-subunits could directly influence α-sub...

Therefore, it was somewhat surprising to find a normal, rather than very above-normal, concentration of glycosylated hemoglobin associated with a highly negatively charged fast hemoglobin variant. This patient was heterozygous for a fast hemoglobin variant; the high proportion of the variant hemoglobin (50%) and the lack of an abnormal HbA2 by cellulose acetate electrophoresis suggest a mutatio...