Glycyrrhiza glabra is a plant used in traditional medicine across the world for its pharmacological value. Its value has been proved such as anti-cough, anti-diabetes, anti-microbial and antioxidant effects. The roots of plant comrised glycyrrhizin which is 50 times sweeter than sugar. Macrophages can stimulated during inflammatory disorders, and with production of multiple inflammatory mediato...

pistachio nut (pistacia vera l.) is one of the most delicious and nutritious nuts in the world. in order to increase the added value of the pistachio nuts, it is necessary to develop new products to meet consumer needs. this is the first paper on pistachio halva. the product was developed using pistachio paste (as main ingredient), mixture of sugar-glucose, egg white and citric acid. the effect...

Phosphatidylglycerols represent a large share of the lipids in plasmamembrane procaryotes. Therefore, this study investigates role charged plasma membrane with respect to interaction antiviral saponin glycyrrhizin such membranes. Glycyrrhizin is natural triterpenic-based surfactant found licorice. Vesicles made 1,2-dioleoyl-sn-glycero-3-phospho-rac-(1’-glycerol) (DOPG)/glycyrrhizin are characte...

A sensitive liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) method was established and validated for the determination of glycyrrhizin in dog plasma. After treatment with methanol to precipitate proteins, plasma samples were analyzed on a reversed-phase C18 (ODS) column with a mobile phase of methanol:1% formic acid solution (75:25, v/v). MS determination was perform...

Liquorice has a long history of use in traditional Chinese, Ayurvedic and herbal medicine. The liquorice plant contains numerous bioactive compounds, including triterpenes, flavonoids secondary metabolites, with glycyrrhizin being the main active compound. constituents have been found to anti-inflammatory, antioxidant, antiviral, anticancer, hepatoprotective neuroprotective properties. In addit...

As the development of the natural medicine, the glycyrrhizin extracted from the licorice root was found to have potential therapeutic value in the treatment of several diseases, especially available for anti-SARS virus . Therefore, the purpose of this work was to find an optimal method to extract and refine the glycyrrhizin. In this work, the extraction of glycyrrhizin by means of organic solve...

Intravenous glycyrrhizin has been used in Japan for the treatment of chronic hepatitis for >20 years, although only a few reports of its pharmacokinetic profile after multiple intravenous doses in small numbers of Japanese patients have been published. The present study compared these Japanese data against the pharmacokinetic characteristics of glycyrrhizin after single and multiple intravenous...

A method for semi-micro high-performance liquid chromatography (HPLC) has been established for the simultaneous determination of 3alpha-hydroxyglycyrrhetic acid and 3-dehydroglycyrrhetic acid together with glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide formed by incubation of glycyrrhizin with rat feces. The analysis was accomplished within 25 min with a TSKgel ODS-80TsQ...

Supramolecular drug delivery systems (DDS) are widely used in pharmacology during last decades for designing new preparations with improved properties. Most of fundamental and applied research in this field has been devoted to the inclusion complexes with cyclodextrins (CD), which are assumed to possess protective properties and to decrease the hydrophobic behavior of the included molecules. At...