EFSA’s remit in the risk assessment of GMOs is very broad encompassing genetically modified plants, microorganisms and animals and assessing their safety for humans, animals and the environment. The legal frame for GMOs is set by Directive 2001/18/EC on their release into the environment, and Regulation (EC) No 1829/2003 on GM food and feed. The main focus of EFSA’s GMO Panel and GMO Unit lies ...

Certified reference materials (CRMs) are an essenIial tool in the quality assurance of analytical measurements. They are produced, certified, and used in accordance with relevant ISO (International Organization for Standardization) and BCR (Community Bureau of Reference) guidelines. The Institute for Reference Materials and Measurements (IRMM; Geel, Belgium) has produced the first powdery genet...

The main objective of this study was to evaluate what would be the economic and environmental consequences of losing the GMO traits in the U.S. for the major crops of corn, soybeans, and cotton. The first step was to obtain from the literature a range of estimates of the yield loses if we move away from GMO traits in the U.S. The second step was to introduce the yield losses obtained in the fir...

In this research, we developed a multiplex polymerase chain reaction (multiplex-PCR) coupled with a DNA microarray system simultaneously aiming at many targets in a consecutive reaction to detect a genetically modified organism (GMO). There are a total of 20 probes for detecting a GMO in a DNA microarray which can be classified into three categories according to their purpose: the first for scr...

For enforcement of the recently introduced labeling threshold for genetically modified organisms (GMOs) in food ingredients, quantitative detection methods such as quantitative competitive (QC-PCR) and real-time PCR are applied by official food control laboratories. The experiences of 3 European food control laboratories in validating such methods were compared to describe realistic performance...

Despite conflicting claims about the performance of Bt cotton, in 2002 the Genetic Engineering Approval Committee approved its commercial cultivation in several states of north India. Judging from the lackadaisical manner in which the genetically modified cotton was handled in the southern and western states, serious doubts about the efficiency of the regulatory agencies persist. More democrati...

What is negative about negative data? Scientists understand negative data from our training in data analysis and statistics, where we use a positive concept of negative data. Negative data are data that do not enable us to reject our null hypothesis. Such data are often difficult to publish because it is not possible to prove the null hypothesis. Every active research scientist has a large draw...

Transdermal delivery of most drugs is precluded by the barrier characteristics of the stratum corneum (SC). Chemical penetration enhancers are capable of interacting with SC constituents, inducing a temporary reversible increase in the skin permeability. The aim of this work was to assess the influence of glycerol monooleate (GMO)/solvents systems on percutaneous absorption across hairless mous...