Photothermal stability and, therefore, consistency of both optical absorption and photoacoustic response of the plasmonic nanoabsorbers is critical for successful photoacoustic image-guided photothermal therapy. In this study, silica-coated gold nanorods were developed as a multifunctional molecular imaging and therapeutic agent suitable for image-guided photothermal therapy. The optical proper...

Introduction Application of near-infrared absorbing nanostructures can induce hyperthermia, in addition to providing more efficient  photothermal effects. Gold-gold sulfide (GGS) is considered as one of these nanostructures. This study was performed on a tissue-equivalent optical-thermal phantom to determine the temperature profile in the presence and absence of GGS and millisecond pulses of a ...

Gold in the form of thio-complexes has been successfully used in the treatment of rheumatoid arthritis for nearly 40 years (Lande, 1927; Pick, 1927), but the mode of action of gold compounds on the diseased connective tissue has yet to be elucidated. In our experiments we have tried to demonstrate the direct binding of gold by collagen because it may be assumed that this type of reaction is sim...

Radiotherapy (RT) is generally considered to be one of the most effective cancer treatments. The primary goal of RT is to accurately induce radiation damage to the tumor while limiting radiation toxicity to a level acceptable to normal tissue. This is accomplished by targeting the tumor with radiation. On the other hand, the status of RT procedures as they stand today is not substantial enough ...

Photothermal-Gas Synergistic Cancer Therapy In article number 2206749, Benhui Hu, Yun Liu, and co-workers propose a cascade reaction-promoted CO release strategy to realize augmented photothermal-gas synergistic cancer therapy. Gold-based porphyrinic coordination polymer nanosheets synthesized by simple aqueous phase reaction, with ultrasmall zero-valent gold as the node, have advantages of hig...

To assess possible associations between human leucocyte antigens (HLA) and the achievement of remission during gold treatment, HLA typing was performed in 67 rheumatoid arthritis (RA) patients with a gold-induced remission and in 25 control RA patients who discontinued gold therapy because of lack of efficacy. Both groups of RA patients showed a significantly higher frequency of DR4 antigen and...

Forestier (1929) first used gold salts to treat rheumatoid arthritis (RA), and controlled studies (e.g. Empire Rheumatism Council, 1960, 1961) later confirmed their effectiveness. An empirical schedule of treatment (conventional chrysotherapy) evolved, using 50 mg. monthly, but this might be further improved if dosage could be adjusted for each patient according to the serum level of gold. Atom...

Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patie...

The early use of gold in medicine and dentistry dates back to the ancient Chinese and Egyptians. The discovery in 1890 that gold salts were toxic in vitro to tubercle bacilli led to the extensive treatment of tuberculosis with gold salts in the first three decades of this century. Eventually, gold therapy was extended to arthritis and lupus erythematosus, because of the belief that these diseas...