A severe gonadotropin deficiency together with chronic estradiol deficiency leading to amenorrhea characterizes patients suffering from hypogonadotropic hypogonadism. Administration of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to these patients has been shown to be essential in achieving successful stimulation of follicular development, ovulation, and rescue of fertil...

Gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) have been implicated as probable risk factors in epithelial ovarian carcinomas, most of which are derived from ovarian surface epithelium (OSE). Since epidermal growth factor (EGF) increases the growth of ovarian surface epithelial cells, we determined the effect of gonadotropins on the expression of epidermal growth...

This literature review focuses on the use of corifollitropin alfa for ovarian stimulation in assisted reproductive technology (ART) programmes different groups patients. Corifollitropin is a gonadotropin drug with prolonged FSH activity. The main difference between and other gonadotropins higher level peak FSH, which leads to recruitment more follicles. Another feature inability adjust dose dur...

such as pregnant mare serum gonadotropin (PMSG) and human menopausal gonadotropin (hMG) is a well-established practical technique. The purpose of this technique is to achieve enhanced commercial production of genetically meritorious individuals in the livestock industry, to retrieve a number of oocytes and early embryos in various research fields including genetic engineering, and to treat medi...

Three glycoprotein hormones comprise the family of gonadotropins in humans, luteinizing hormone (LH), chorionic gonadotropin (CG), and fol l icle-stimulating hormone (FSH), composed of a common a subunit and a hormone-specific � subunit. These heterodimers act via two G protein-coupled receptors, the LH receptor (LHR) and the FSH receptor (FSHR), that are expressed on gonadal cells. The � subun...

INTRODUCTION Although rapid progress has been made in improving fertility in women, the treatment of an infertile male has remained very unsatisfactory. This situation is partly due to paucity of our knowledge regarding the factors controlling spermatogenesis in man. The role of testosterone and gonadotropins in the maintenance of spermatogenesis is not clearly understood (Steinberger, 1971). N...