نتایج جستجو برای: gra

تعداد نتایج: 1087  

2004
Yang-Cheng Lin

This paper presents a consumer oriented approach, using a grey relational analysis (GRA), neural networks (NNs), and a tabu search (TS) algorithm, to determining the best combination of product form design. The GRA model is used to identify the most influential elements of product form. The NN model is used in conjunction with the GRA model, in order to predict and suggest the best form design ...

Journal: :Bioscience, biotechnology, and biochemistry 2008
Yumiko Yoshikawa Hirofumi Hirayasu Satoshi Tsuzuki Tohru Fushiki

Granzyme A (GrA) is a serine protease produced in cytotoxic lymphocytes, lung epithelial cells (alveolar type-II cells), and alveolar macrophages. In the present study, recombinant rat GrA (rGrA) was found to cause rounding and detachment of an alveolar type-II epithelial cell line, A549. Also, rGrA stimulated release of a neutrophil chemoattractant, interleukin-8, from the cells, via a mechani...

2014
Jay M. Hendricks Diana C. Lowe Michele E. Hardy

18β-glycyrrhetinic acid (GRA) is a pharmacologically active component of licorice root with documented immunomodulatory properties. We reported that GRA administered orally to mice induces B cell recruitment to isolated lymphoid follicles (ILF) in the small intestine and shortens the duration of rotavirus antigen shedding. ILF are dynamic lymphoid tissues in the gut acquired post-natally upon c...

Journal: :CoDAS 2013
Patricia Arruda de Souza Alcarás Adriana Bender Moreira de Larcerda Jair Mendes Marques

PURPOSE To analyze the findings for Evoked Otoacoustic Emissions (EOEA) and suppression effect in workers with normal hearing exposed to pesticides and noise . METHODS The sample consisted of 55 participants with normal hearing, with ages ranging from 18 to 35 years, divided into two groups: one group exposed to noise and pesticides (GRA) and a control group (CG). The GRA was composed of 25 p...

Journal: :The Journal of clinical endocrinology and metabolism 1998
A A MacConnachie K F Kelly A McNamara S Loughlin L J Gates G C Inglis A Jamieson J M Connell N E Haites

Glucocorticoid remediable aldosteronism (GRA) is an autosomal dominant cause of primary aldosteronism and high blood pressure resulting from a chimeric 11beta-hydroxylase/aldosterone synthase gene. Abnormal expression of aldosterone synthase causes primary aldosteronism, which can be inhibited by glucocorticoids. Diagnosis of GRA has depended on the identification of a restriction enzyme produc...

2016
Donghui Cao Zhifang Jia Lili You Yanhua Wu Zhen Hou Yueer Suo Houjun Zhang Simin Wen Tetsuya Tsukamoto Masanobu Oshima Jing Jiang Xueyuan Cao

18β-glycyrrhetinic acid (GRA) exerts anti-tumor effects on various types of cancer. In the present study, we found that GRA attenuated the severity of gastritis and suppressed gastric tumorigenesis in transgenic mice. We also discovered that miR-149-3p was downregulated in gastric cancer tissues and cell lines as compared to normal gastric tissues and epithelial cells, but was upregulated by GR...

Journal: :Antimicrobial agents and chemotherapy 2015
Purnima Gupta Pijush K Das Anindita Ukil

18β-Glycyrrhetinic acid (GRA), a natural immunomodulator, greatly reduced the parasite load in experimental visceral leishmaniasis through nitric oxide (NO) upregulation, proinflammatory cytokine expression, and NF-κB activation. For the GRA-mediated effect, the primary kinase responsible was found to be p38, and analysis of phosphorylation kinetics as well as studies with dominant-negative (DN...

2009
J. M. Sunshine R. D. Ash R. J. Walker Y. Liu D. Rumble W. F. McDonough L. A. Taylor

GRA 06128/9: Since their discovery at Graves Nunataks icefield during the 2006/2007 Antarctic Search for Meteorites field season, GRA 06128 and GRA 06129 have received considerable scientific attention. Their elevated modal abundances of oligoclase (>75%), blocky or slab-like character, granoblastic textures and ‘andesitic’ bulk compositions set them apart from all other meteorite classes. It h...

2013
Georg M. Schmölzer Megan O'Reilly Shaun Cowan Sharon Qin David L. Bigam

Me Me M di di dic ca cal l Un Un Univ iv iver er e si si sity ty ty G G Gra ra raz, z, G G Gra ra raz, z, z A A Aus us str tr tria ia ia Abstract Background—Guidelines on neonatal resuscitation recommend 90 chest compressions (CC) and

2009
N. M. Abreu G. L. Stanek

Introduction: Several studies have contributed to our understanding of the record of alteration of CR chondrites [e.g., 1-5]. However, recent observations of CR2 GRA 06100 suggest that hydration of the CR parent body was a more diverse process than previously anticipated [6]. [6] observed that Fe,Ni metal in this meteorite was invariably and extensively altered to form complex assemblages conta...

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