Treg cells hold enormous promise for therapeutic application in GVH disease, a lethal complication of allogeneic HSC transplantation. Mouse studies showed that donor-derived recipient-specific Treg (rsTreg) cells are far more efficient than polyclonal Treg cells in suppressing GVH disease. However, clinical grade preparations of rsTreg cells carries the risk of containing significant numbers of...

Blockade of the CD40 and CD28 costimulatory pathways significantly prolongs allograft survival; however, certain strains of mice (i.e., C57BL/6) are relatively resistant to the effects of combined CD40/CD28 blockade. We have previously shown that the costimulation blockade-resistant phenotype can be attributed to a subset of CD8+ T cells and is independent of CD4+ T cell-mediated help. Here we ...

The reactivity of lymphoid cells from germfree and conventional CDF rats were compared in mixed leukocyte culture (MLC) with both allogeneic rat leukocytes and with human leukocytes as stimulating cells, and in a graft-versus-host (GVH) assay. There was no difference between germfree and conventional rats in any of these systems. Furthermore, the increase in GVH activity after specific immuniza...

Background: In this article we consider how the question of what music can or cannot do is linked to the kind of light cast upon musical engagement and its outcomes. Methods: We describe how a concern with flourishing, as opposed to a concern with more conventional understandings of ‘health’ versus ‘illness’, can help to illuminate some of otherwise invisible processes by which music ‘helps’. R...

This study differentiates female entrepreneurs from male entrepreneurs using the Big-Five Personality Model. The five factors include adjustment, sociability, conscientiousness, agreeableness, and intellectual openness. Adjustment determines confidence versus instability. Sociability measures extraversion versus introversion. Conscientiousness determines impulsiveness versus cautiousness. Agree...

This study aimed to investigate the surface roughness and gloss of composite resins after using two polishing systems and toothbrushing. Six composite resins (Durafill VS, Filtek Z250, Filtek Z350 XT, Kalore, Venus Diamond, and Venus Pearl) were evaluated after polishing with two polishing systems (Sof-Lex, Venus Supra) and after toothbrushing up to 40,000 cycles. Surface roughness (Ra) and glo...

The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T-cell response which is specific for anti-major hostocompatibility complex receptors on parental T cells. This protective...

tributed equally to this study. Study concept and design: C. Lim and S.-L. Lim. Acquisition of data: C. Lim and S.-L. Lim. Analysis and interpretation of data: C. Lim and S.-L. Lim. Drafting of the manuscript: C. Lim and S.-L. Lim. Critical revision of the manuscript for important intellectual content: C. Lim and S.-L. Lim. Administrative, technical, and material support: C. Lim and S.-L. Lim. ...