Methodology and Measurement in the Behavioral and Social Sciences (R01) The behavioral and social sciences offer insights into the comprehensive understanding of human health, including disease etiology and treatment, and the promotion of health and well-being. To encourage the investigation of the impact of social and behavioral factors on health and disease, the participating institutes and c...

The presence of inflammatory cells in human malignant tumours has been well known for nearly a century. Many authors have suggested the round cell infiltration in and around the tumours as a reaction reflecting host resistance against malignancy. (Underwood, 1974; loachim, 1976). It has been difficult to define histopathological characteristics of prognostic value in relation to the local infla...

The National Institute of General Medical Sciences (NIGMS) currently supports the analysis of complex biological systems through investigator-initiated research project grants. The resources needed to conduct the multifaceted, multidisciplinary projects that may be required to achieve significant advances in these complex areas may be beyond the scope of the typical R01 or P01 grant. Therefore,...

We applied three approaches for the identification of polymorphisms explaining the linkage evidence to the Genetic Analysis Workshop 14 simulated data: 1) the genotype-IBD sharing test (GIST); 2) an approach suggested by Horikawa and colleagues; and 3) the homozygote sharing test (HST). These tests were compared with a family-based association test. Two linked regions with highest nonparametric...

Internship Opportunities in Bioethics The NIEHS is offering a limited number of internships in environmental policy and ethics. Interns participating in the Program in Environmental Health Policy and Ethics (PEHPE) examine policy issues and conduct research under the guidance of a faculty mentor. Potential projects examine issues in environmental regulation and policy, impact of new technologie...

Background: Damask roses (Rosa damascena Mill.) are mainly used for essential oil production. Previous studies have indicated that all production material in Bulgaria and Turkey consists of only one genotype. Nine polymorphic microsatellite markers were used to analyze the genetic diversity of 40 accessions of R. damascena collected across major and minor rose oil production areas in Iran. Resu...

Homing endonucleases are site-specific and rare cutting endonucleases often encoded by intron or intein containing genes. They lead to the rapid spread of the genetic element that hosts them by a process termed ‘homing’; and ultimately the allele containing the element will be fixed in the population. PI-SceI, an endonuclease encoded as a protein insert or intein within the yeast V-ATPase catal...

Background: Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases. On the biotechnological side, protein production is often hampered by the accumulation of recombinant proteins into aggregates. Thus, the development of methods to anticipate the aggregation properties of polypeptides is rece...

Chemicals The purpose of this program announcement (PA) is to investigate acute mucosal irritation in the upper and lower respiratory tract occurring after aerosol exposure to toxic chemicals with the goals to: 1) minimize initial injury promptly, 2) retard and ameliorate progressive mucosal irritation or inflammation, and 3) offer prophylaxis against pulmonary edema, if created by acute lung i...