The decrease in the rms contrast of time-averaged images with the averaging time is compared between four datasets: (1) a series of solar granulation images recorded at La Palma in 1993; (2) a series of artificial granulation images obtained in numerical simulations by Rieutord et al. (2002); (3) a similar series computed by Steffen and his colleagues (see Wedemeyer et al., 2004); (4) a random ...

The utilization of negative pressure for medicinal purposes dates back to 600 bc. The U.S. military has been engaged in continuous overseas combat operations since 2001. Negative-pressure wound therapy has been in use in the treatment of casualties from these operations since 2004. It represents a new standard of practice in combat wound care; it promotes granulation tissue formation and create...

In this paper multi granulation rough sets is extended to variable precision to develop a model for multi-granulation variable precision rough sets. We define a lower approximation of the model and address the significance of granularity as heuristic information. We extend the ideas and design a granular space reduction algorithm of multi-granulation variable precision rough sets. Finally, an e...

sion/spheronization affects the properties of the resulting pellets. Pharmaceutical scientists originally directed their focus to extrusion, spheronization and drying which can be seen from the literature. Only a few authors reported investigations concerning the impact of the granulation step. Baert et al. investigated ternary mixtures of microcrystalline cellulose (MCC), a drug substitute and...

In most formulations processed via continuous twin screw granulation microcrystalline cellulose (MCC) and/or lactose are used as excipients, but mannitol is also a preferred excipient for wet granulation and tableting due to its non-hygroscopicity and inertness. Therefore, the aim of the current study was to investigate the influence of process parameters on critical quality attributes of granu...

Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcryst...

Complications of tracheotomy tube placement can be categorized as intraoperative, early postoperative, and late postoperative. Among the late complications is the development of granulation tissue. We describe one of the few reported cases of granulation tissue that formed within a fenestrated tracheotomy tube. In this case, the granulation tissue grew through the fenestrations, obliterated the...

Wet granulation using foaming binder solution is a new approach of liquid delivery to create granules. This study compares wet granulation via foamed binder addition method and sprayed binder addition method by studying the kinetics of foam and drop penetrations into loosely packed powder beds. Foam and drop nucleation kinetics were compared by examining specific penetration time (penetration t...

Proteinases play a pivotal role in wound healing by regulating cell-matrix interactions and availability of bioactive molecules. The role of matrix metalloproteinase-13 (MMP-13) in granulation tissue growth was studied in subcutaneously implanted viscose cellulose sponge in MMP-13 knockout (Mmp13(-/-)) and wild type (WT) mice. The tissue samples were harvested at time points day 7, 14 and 21 an...

We successfully used argon plasma coagulation (APC) and tranilast to treat granulation tissue that had formed on an end-to-end tracheal anastomosis. APC had several advantages over laser in the management of exuberant granulation tissue, and we considered tranilast to be effective in our patient. To our knowledge, this is the first description of the use of APC in the management of anastomotic ...