OBJECTIVE To determine the inter-rater reliability of the Institute for Healthcare Improvement's Global Trigger Tool (GTT) in a practice setting, and explore the value of individual triggers. DESIGN Prospective assessment of application of the GTT to monthly random samples of hospitalized patients at four hospitals across three regions in the USA. SETTING Mayo Clinic campuses are in Minneso...

OBJECTIVE To test the hypothesis that glucose ingestion leads to a decrease in plasma ionized calcium (iCa) and ionized magnesium (iMg) during the third trimester of pregnancy. METHODS We studied 54 women who underwent a 50 g glucose challenge test (GCT) and 27 women who underwent a 3-hour 100 g glucose tolerance test (GTT) because of an abnormal GCT. Plasma glucose was measured with an autom...

The beneficial antithrombotic effect of some dietary components may offer the most promising approach of prevention of cardiovascular diseases and arterial thrombosis. The major stumbling block in finding effective dietary components is the lack of physiologically relevant techniques which can detect potential antithrombotic effect in humans. The presently used platelet function and coagulation...

Harper KM, Tunc-Ozcan E, Graf EN, Redei EE. Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response. Physiol Genomics 46: 159–168, 2014. First published January 14, 2014; doi:10.1152/physiolgenomics.00181.2013.—Consequences of prenatal exposure to ethanol (E) include morphological, physiological, and cognitive deficits and are collectively classified as fetal alc...

The bioavailability of soybean isoflavones varies widely among individuals due to many factors, including activities of gut microflora. To characterize factors that affect fecal isoflavone disappearance phenotype and isoflavone bioavailability in women, 35 Asian and 33 Caucasian women, 18-43 y of age, provided fecal samples for anaerobic incubation with isoflavones in vitro at two times 5 mo ap...

A morphometric evaluation of second-stage juveniles (J2), males, females, cysts, and eggs of several isolates of the tobacco cyst nematode (TCN) complex, Globodera tabacum tabacum (GTT), G. t. virginiae (GTV), and G. t. solanacearum (GTS) is presented. Morphometrics of eggs, J2, and males are considerably less variable than of females and cysts. No measurements of eggs and J2 are useful for ide...

The objective of this study was to assess the effects of the season, travel duration and trailer compartment location on blood creatine-kinase (CK), lactate and cortisol concentrations in 384 pigs and assess their relationships with trailer temperature, heart rate and gastrointestinal tract temperature (GTT), behavior, carcass damage scores and meat quality. Blood CK was greater in pigs transpo...

BACKGROUND As a part of a larger study investigating the effects of alpha-tocopherol on gene expression in type 2 diabetics we observed a pro-oxidant effect of alpha-tocopherol which we believe may be useful in interpreting outcomes of large intervention trials of alpha-tocopherol. METHODS 19 type 2 diabetes subjects were randomised into two groups taking either 1200 IU/day of alpha-tocophero...

A retrospective study to evaluate the characteristics of brain metastatic patients with gestational trophoblastic tumors (GTT) and to analyze the results of treatment has been performed. During 1996-2001, 40 patients with metastatic GTT were diagnosed at Vali-e-Asr Hospital, Tehran, Iran. Of them, nine with brain metastases, which were documented with the help of computed tomography scan, were ...