نتایج جستجو برای: h1n1 subtype
تعداد نتایج: 65686 فیلتر نتایج به سال:
BACKGROUND Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum levels of IP-10 (interferon-gamma-inducible protein-10). Furthermore, when compared with human influenza virus subtype H1N1, the H5N1 viruses ...
27 28 The recent association of certain Influenza A subtypes with clinically relevant phenotypes has 29 led to the increasing importance of subtyping by clinical virology laboratories. To provide 30 clinical laboratories with a definitive immunofluorescence assay for the subtyping of influenza A 31 virus isolates, we generated a panel of monoclonal antibodies (MAbs) against the major 32 circula...
Background: Swine influenza viruses (SIVs) of H1N2 subtype have recently become established in several European countries, and they cocirculate with H1N1 and H3N2 viruses. The H1N2 virus haemagglutinin (HA) appears to be of human origin and fails to cross-react with avian-like H1N1 SIVs in vitro. This study examines whether in vivo cross-protection occurs between H1N1 and H1N2 viruses isolated ...
Influenza virus infection is a significant cause of morbidity and mortality worldwide. The surface antigens of influenza virus change over time blunting both naturally acquired and vaccine induced adaptive immune protection. Viral antigenic drift is a major contributing factor to both the spread and disease burden of influenza. The aim of this study was to develop better infection models using ...
Rapid detection of influenza A virus and determination of its subtype are important globally for public health surveillance and locally for the selection of antiviral treatment (1). We have used the ProFlu assay to test respiratory samples from children for influenza A virus, influenza B virus, and respiratory syncytial virus (RSV) and the ProFlu ST test to subtype influenza A virus (Gen-Probe ...
swine flue is a highly contagious acute respiratory disease caused by a subtype of influenza a virus. herein we present three patients with h1n1 infection complicated with pulmonary thromboembolism. the patients had chest pain and unexplained dyspnea. imaging studies showed bilateral hilar predominance. computed tomographic angiography confirmed bilateral thromboembolism (an unusual presentatio...
During the 2013/14 influenza season in Canada, 631 of 654 hospitalisations for laboratory-confirmed influenza enrolled in sentinel hospitals were due to Influenza A. Of the 375 with known subtype, influenza A(H1N1) accounted for 357. Interim unmatched vaccine effectiveness adjusted for age and presence of one or more medical comorbidities was determined by test-negative case-control design to b...
To the Editor: Accumulating evidence suggests that the degree of serologic crossreactivity to pandemic (H1N1) 2009 virus varies between populations worldwide. To assess potential serologic cross-reactivity in Singapore, we obtained serum samples during May–June 2009 from 50 randomly recruited, healthy volunteers born mostly before 1958 (i.e., potentially those with some natural exposure to the ...
We have generated recombinant influenza A viruses belonging to the H1N1 and H3N2 virus subtypes containing an insertion of the 137 C-terminal amino acid residues of the human immunodeficiency virus type 1 (HIV-1) Nef protein into the influenza A virus nonstructural-protein (NS1) reading frame. These viral vectors were found to be genetically stable and capable of growing efficiently in embryona...
BACKGROUND During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. METHODS We tested serum specimens obtained from 182 individuals aged 1...
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