BACKGROUND The past two decades have seen a large increase in investment in global public health research. There is a need for increased coordination and accountability, particularly in understanding where funding is being allocated and who has capacity to perform research. In this paper, we aim to assess global, regional, national and sub-national capacity for public health research and how it...

The control of coagulation enzymes by antithrombin is vital for maintenance of normal hemostasis. Antithrombin requires the co-factor, heparin, to efficiently inhibit target proteinases. A specific pentasaccharide sequence (H5) in high affinity heparin induces a conformational change in antithrombin that is particularly important for factor Xa (fXa) inhibition. Thus, synthetic H5 accelerates th...

BACKGROUND Numerous Asian cases of avian influenza virus infection, especially the highly pathogenic strain H5N1, in humans have raised the concern that another influenza pandemic is close. However, there are no effective therapeutic drugs or preventative vaccines available. Hemagglutinin is the membrane glycoprotein of avian influenza virus responsible for receptor binding to human cells and t...

Rapid and differential diagnosis of highly pathogenic avian influenza virus (HPAIV) subtype H5 is essential for the effective prevention and control of outbreaks caused by this pathogen. In this study, we describe a one-step multiplex real-time reverse transcription polymerase chain reaction (mRRT-PCR), using H5-, N1-, and N8-specific primers and probes, for differential detection of two HPAIVs...

The [H5]phenylalanine model was compared with the [1-C]leucine method to determine whole body protein synthesis (WBPS) and degradation (WBPD) in sheep fed at two levels. The animals were fed either 103 (M-diet) or 151 (H-diet) kcal ME/kg/day once daily in a crossover design for 21 days each. The isotope dilutions were simultaneously conducted as a primedcontinuous infusion of [H5]phenylalanine,...

Krauss et al. (1) use lack of detection of highly pathogenic (HP) H5 clade 2.3.4.4 (henceforth “H5”) influenza A viruses (IAVs) from >22,000 wild bird samples collected in North America in 2014–2015 to argue that HP H5 IAVs disappeared from waterfowl and that unresolved mechanisms restrict emergence and perpetuation of HP IAVs in natural reservoir species. Here we offer an alternative interpret...

The Ceylon Journal of Science is a peer-reviewed journal published quarterly by the University Peradeniya, Sri Lanka in March, June, September and December. It aimed at publishing high quality research articles on topics related to different disciplines Science. accepts original articles, book reviews, reviews mini-reviews, short communications, opinions, notes, commentaries notes. has its own ...

The Ceylon Journal of Science is a peer-reviewed journal published quarterly by the University Peradeniya, Sri Lanka in March, June, September and December. It aimed at publishing high quality research articles on topics related to different disciplines Science. accepts original articles, book reviews, reviews mini-reviews, short communications, opinions, notes, commentaries notes. has its own ...

The Ceylon Journal of Science is a peer-reviewed journal published quarterly by the University Peradeniya, Sri Lanka in March, June, September and December. It aimed at publishing high quality research articles on topics related to different disciplines Science. accepts original articles, book reviews, reviews mini-reviews, short communications, opinions, notes, commentaries notes. has its own ...