Ivermectin (IVE), one of the most important anthelmintics, is often used in the treatment of haemonchosis in ruminants. The objective of our work was (1) to find and identify phase I and II metabolites of IVE formed by the Barber's pole worm (Haemonchus contortus), and (2) to compare IVE metabolites in helminths with IVE biotransformation in sheep (Ovis aries) as host species. Ultrahigh-perform...

Ten female lambs of 7-month-old were divided into two equal groups and raised under a helminth-free conditions. Animals in group 1 were immunized two times by whole gut homogenate (WGH) of Haemonchus contortus emulsified in Freund’s adjuvant. In group 2 (control), animals were injected by phosphate buffered saline emulsified in the same adjuvant. Animals were challenged by 10000 third-stage lar...

Background: The most important genera of trichostrongylid nematodes that live in digestive tract of ruminants include Teladorsagia, Haemonchus, Trichostrongylus, Cooperia and Marshallagia. Out of the above-mentioned genera, four infect humans including Teladorsagia, Haemonchus, Trichostrongylus and Marshallagia. These parasites are an important part of ruminant pathogens, and some are extremely...

Resistance to eprinomectin was suspected in a dairy sheep farm southwestern France. The efficacy of topical and injection formulations against gastrointestinal nematodes (GINs) compared using faecal egg count reduction test. GIN species were identified by real-time PCR, concentrations measured serum High-Performance Liquid Chromatography 2 5 days after treatment. Efficacies 99.6% 86.1% for form...

Trichostrongylids infection has gained significant public health importance since Trichostrongylus spp. infections have been reported in humans in Lao PDR. In this study, gastrointestinal nematodes were identified and the intensity of infections was determined in goats and cattle, which are animals greatly used for meat production in Lahanam Village, Lao PDR. The total number of goats and bovin...

Infective larvae of selected batched of the following nematode species from sheep and cattle were examined for survival and infectivity (by injection into either the abomasum, the duodenum, or the jugular vein) after having been stored in liquid nitrogen for 103-136 months: Haemonchus contortus, Haemonchus placei, Ostertagia circumcincta, Ostertagia ostertagi, Marshallagia marshalli, Cooperia s...

Objective: To explore the efficacy of ethanolic leaf extract of Aristolochia indica L. in bacterial and worm infections using experimental models. Methods: Preliminary phytochemical screening was evaluated by following standard procedure. Antibacterial activity was carried out by disc diffusion method and anthelmintic effect of the plant extract was determined based on time taken for paralysis ...

It was evaluated the anthelmintic activity of Agave sisalana (sisal) juice against gastrointestinal nematodes and its potential toxic effects in goats. In vitro tests showed more than 95% reduction in larval counts of the genus Haemonchus spp. at concentrations between 86.5 and 146.3 mg.mL(-1). In vivo the percent reduction of larvae of the fourth (L4) and fifth (L5) stages of Haemonchus, Oesop...

Exsheathed infective larvae (L3) of 16 species of nematodes were tested for infectivity in either sheep or cattle after they had been frozen and stored in 0,09% NaCl solution in the gas phase of liquid nitrogen for periods of up to 59 months. A mean of greater than 90% of the L3 of Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Nematodirus ...

REINECKE, R. K. Studies on Haemonchus contortus l. The influence of previous exposure to Trichostrongylus axei on infestation with H . cantor/us. Onderstepoort J. vet. Res. 41 (4) , 213216 (1974) . A group of Merino sheep, aged 67 months was infested orally with 50 000 infective larvae of Trichostrongylus axei. This group and a control group were challenged 9092 days later with 50 000 infective...