The exposure-responses for several effects of limited exposures to diethylnitrosamine (DEN) in the livers of male Fischer 344 rats were measured and phenobarbital promotion was used to enhance expression of initiation of carcinogenesis. Five doses ranging from a cumulative total of 0.5 to 4 mmol DEN per kg body weight were given as weekly i.p. injections for 10 weeks. This was followed by 4 wee...

BACKGROUND Skin atrophy is a common manifestation of aging and is frequently accompanied by ulceration and delayed wound healing. With an increasingly aging patient population, management of skin atrophy is becoming a major challenge in the clinic, particularly in light of the fact that there are no effective therapeutic options at present. METHODS AND FINDINGS Atrophic skin displays a decrea...

We examined optical fibers suitable for avoiding such problems as the fiber fuse phenomenon and failures at bends with a high power input. We found that the threshold power for fiber fuse propagation in photonic crystal fiber (PCF) and hole-assisted fiber (HAF) can exceed 18 W, which is more than 10 times that in conventional single-mode fiber (SMF). We considered this high threshold power in P...

Methods for detecting the genomic signatures of natural selection have been heavily studied, and they have been successful in identifying many selective sweeps. For most of these sweeps, the favored allele remains unknown, making it difficult to distinguish carriers of the sweep from non-carriers. In an ongoing selective sweep, carriers of the favored allele are likely to contain a future most ...

This study assessed the utility of CT perfusion for quantitative assessment of liver function and fibrosis. Tissue blood flow (TBF), tissue blood volume (TBV), mean transit time (MTT) and hepatic arterial fraction (HAF) were measured with CT perfusion using the deconvolution algorithm in 38 patients with chronic liver diseases and 10 patients without liver disease. Using Child-Pugh classificati...

The high-order ambiguity function (HAF) was introduced for the estimation of polynomial-phase signals (PPS) embedded in noise. Since the HAF is a nonlinear operator, it suffers from noise-masking effects and from the appearance of undesired crossterms whenmulticomponents PPS are analyzed. In order to improve the performances of the HAF, the multi-lag HAF concept was proposed. Based on this appr...

Parameter estimation of polynomial phase signals (PPSs) is of great interest in various practical applications. In this paper, parametric methods for parameter estimation of polynomial phase signals are discussed and compared. The suboptimal maximum likelihood estimation methods, such as the high-order ambiguity function (HAF) and the product HAF (PHAF) are presented. The polynomial time freque...

We propose novel algorithms to select and extract separately all the components, using the time-frequency distribution (TFD), of a given multicomponent frequency-modulated (FM) signal. These algorithms do not use any a priori information about the various components. However, their performances highly depend on the cross-terms suppression ability and high time-frequency resolution of the consid...

Air classification (AC) is a cost-effective technology that separates the energy-dense light ash fraction (LAF) from inorganic-rich high (HAF) of corn stover. HAF could be upgraded into solid fuel by hydrothermal carbonization (HTC). However, HTC high-temperature, high-pressure process, which requires additional energy to operate. In this study, three different scenarios (i.e., AC only, and int...

the thermally stimulated discharge (tsdc) current is studied for acrylonitrile butadiene rubber (nbr) loaded with different high abrasion furnace carbon black (haf). tsdc peak appears only for higher haf contents > 60phr (70 and 80phr of haf contents), the tsdc spectra consist of a sharp peak corresponding to a peak temperature tm which is slightly shifted to higher temperature for 70phr ...