−Animals have typically been used in efficacy tests, but there are a number of dissimilarities between humans and animals. To overcome the problems associated with animal testing, a model which is reproduced in vitro with longterm culture with cell growth with in vivo activity must be developed. We made a gel-type dermal equivalent (DE) that contained dermal papilla cells (DPCs) or dermal sheat...

OBJECTIVES Cornu cervi pantotrichum (CCP) has been widely used in Korean and China, as an anti-fatigue, anti-aging, and tonic agent to enhance the functions of the reproductive and the immune systems. Because CCP has various growth factors that play important roles in the development of hair follicles, we examined whether CCP pharmacopuncture solution (CCPPS) was capable of promoting hair growt...

Background: One of the key questions in biochemistry is why cell becomes aged and what are the involved factors? Why cell growth is stopped after some divisions and cells become senescent? This occurs in a greater frame in the whole body and cells dye after a while. Androgenetic alopecia (AGA) is characterized by a loss or decrease in hair follicle size, which could be related to the loss of ha...

Here, we studied hair follicle development of Liaoning Cashmere goats. Every month for 1 year, skin samples were collected from five 1.5-year-old female goats, and made into paraffin sections. A number of parameters were measured of primary and secondary hair follicles via microscopic observation including follicle depth, hair bulb width, dermis and epidermis thickness, changes in follicle acti...

ROOT HAIR DEFECTIVE SIX-LIKE4 (RSL4) is necessary and sufficient for root hair elongation in Arabidopsis thaliana. Root hair length is determined by the duration for which RSL4 protein is present in the developing root hair. The aim of this research was to identify genes regulated by RSL4 that affect root hair growth. To identify genes regulated by RSL4, we identified genes whose expression was...

Multiple nutritional, environmental and lifestyle factors can directly affect hair follicles or weaken and make them sensitive to the action of androgens. Patients having hair fall, thinning and poor growth can be in early stages of androgenetic alopecia. Hair loss can be corrected and hair growth can be improved by addressing these nonandrogenic factors. Recent research has shown that androgen...

Background: The Dermal Papilla (DP) consists in specialized dermal fibroblasts located at the base of hair follicles and secreting extracellular matrix, especially collagen and glycosaminoglycans. DP cells are responsible for the production of hair fibers, by inducing anagen phase, and by maintaining the hair in this growth phase. Miliacin (contained in millet oil) is known for its healing prop...

One of the most common side effects of treatment with cyclosporin A (CsA) is hypertrichosis. This study shows that calcineurin activity is associated with hair keratinocyte differentiation in vivo, affecting nuclear factor of activated T cells (NFAT1) activity in these cells. Treatment of nude or C57BL/6 depilated normal mice with CsA inhibited the expression of keratinocyte terminal differenti...

background: due to the presence of radioactive minerals such as monazite, the beach sand of the west coast of kanyakumari exhibits high natural background radiation. hair is a good indicator of radionuclides in the human body. an attempt is taken to measure the 210po activity in human hair samples and the factors affecting it. material and methods: 210po activity was analysed in 47 individuals ...