The neural simulation tool NEST can simulate small to very large networks of point-neurons or neurons with a few compartments. In this chapter, we show by example how models are programmed and simulated in NEST. This document is based on a preprint version of Gewaltig et al. (2012) and has been updated for NEST 2.6 (r11744). Updated to 2.6.0 Hans E. Plesser, December 2014 Updated to 2.4.0 Hans ...