نتایج جستجو برای: hansenula polymorpha

تعداد نتایج: 1687  

Journal: :Applied and environmental microbiology 2007
Jeong-Nam Park Min Jeong Sohn Doo-Byoung Oh Ohsuk Kwon Sang Ki Rhee Cheol-Goo Hur Sang Yup Lee Gerd Gellissen Hyun Ah Kang

The genomewide gene expression profiling of the methylotrophic yeast Hansenula polymorpha exposed to cadmium (Cd) allowed us to identify novel genes responsive to Cd treatment. To select genes whose promoters can be useful for construction of a cellular Cd biosensor, we further analyzed a set of H. polymorpha genes that exhibited >6-fold induction upon treatment with 300 muM Cd for 2 h. The put...

Journal: :Microbial Cell Factories 2009
Christoph Stöckmann Marco Scheidle Barbara Dittrich Armin Merckelbach Grit Hehmann Georg Melmer Doris Klee Jochen Büchs Hyun Ah Kang Gerd Gellissen

A range of industrial H. polymorpha-based processes exist, most of them for the production of pharmaceuticals. The established industrial processes lean on the use of promoters derived from MOX and FMD, genes of the methanol metabolism pathway. In Hansenula polymorpha these promoters are de-repressed upon depletion of a range of carbon sources like glucose and glycerol instead of being induced ...

2011
Vira M Ubiyvovk Vladimir M Ananin Alexander Y Malyshev Hyun Ah Kang Andriy A Sibirny

BACKGROUND Tripeptide glutathione (gamma-glutamyl-L-cysteinyl-glycine) is the most abundant non-protein thiol that protects cells from metabolic and oxidative stresses and is widely used as medicine, food additives and in cosmetic industry. The methylotrophic yeast Hansenula polymorpha is regarded as a rich source of glutathione due to the role of this thiol in detoxifications of key intermedia...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
K N Faber P Haima C Gietl W Harder G Ab M Veenhuis

Two main types of peroxisomal targeting signals have been identified that reside either at the extreme C terminus (PTS1) or the N terminus (PTS2) of the protein. In the methylotrophic yeast Hansenula polymorpha the majority of peroxisomal matrix proteins are of the PTS1 type. Thus far, for H. polymorpha only amine oxidase (AMO) has been shown to contain a PTS2 type signal. In the present study ...

2012
Sanjeev Kumar Sophie D. Lefevre Marten Veenhuis Ida J. van der Klei

BACKGROUND Chronological aging of yeast cells is commonly used as a model for aging of human post-mitotic cells. The yeast Saccharomyces cerevisiae grown on glucose in the presence of ammonium sulphate is mainly used in yeast aging research. We have analyzed chronological aging of the yeast Hansenula polymorpha grown at conditions that require primary peroxisome metabolism for growth. METHODO...

Journal: :FEMS yeast research 2005
Marco V Lutz Roel A L Bovenberg Ida J van der Klei Marten Veenhuis

The enzyme acetyl-CoA:isopenicillin N acyltransferase (IAT) is a peroxisomal enzyme that mediates the final step of penicillin biosynthesis in the filamentous fungi Penicillium chrysogenum and Aspergillus nidulans. However, the precise role of peroxisomes in penicillin biosynthesis is still not clear. To be able to use the power of yeast genetics to solve the function of peroxisomes in penicill...

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