نتایج جستجو برای: haplotype analysis
تعداد نتایج: 2832840 فیلتر نتایج به سال:
It is common to have missing genotypes in practical genetic studies, but the exact underlying missing data mechanism is generally unknown to the investigators. Although some statistical methods can handle missing data, they usually assume that genotypes are missing at random, that is, at a given marker, different genotypes and different alleles are missing with the same probability. These inclu...
• Lynx bones were found at Castellum Albaniana in the Netherlands. Q-PCR and sequencing identified lynx mitochondrial DNA sequences. haplotype was not identical to ancient remains matched with a Southern European haplotype. In 2001 2002 an excavation conducted town of Alphen aan den Rijn Netherlands revealed vestiges Roman fort, , situated along historical Rhine delta used for centuries during ...
The genome-wide association study (GWAS) has become a routine approach for mapping disease risk loci with the advent of large-scale genotyping technologies. Multi-allelic haplotype markers can provide superior power compared with single-SNP markers in mapping disease loci. However, the application of haplotype-based analysis to GWAS is usually bottlenecked by prohibitive time cost for haplotype...
AKT-glycogen synthase kinase 3beta (GSK3beta) signaling is a target of lithium and has been implicated in the pathogenesis of mood disorders and schizophrenia. AKT1 protein level is decreased in the peripheral lymphocytes and brains of schizophrenic patients. The SNP2/3/4 TCG haplotype of AKT1 was associated with schizophrenia in patients with Northern European origin. In the present study, we ...
We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also ...
A general algorithm is described for haplotype analysis of unrelated individuals with missing genotypes. It can handle problems involving multiple polymorphic markers with missing data.
Multi-locus association analyses, including haplotype-based analyses, can sometimes provide greater power than single-locus analyses for detecting disease susceptibility loci. This potential gain, however, can be compromised by the large number of degrees of freedom caused by irrelevant markers. Exhaustive search for the optimal set of markers might be possible for a small number of markers, ye...
SUMMARY We implement a program that incorporates polymorphic sites data, haplotype frequency arrays, and other factors, into cladogram estimation.
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