BACKGROUND Diabetes and cardiovascular disease have emerged as key threats to human health, and the risk is increased in individuals with visceral obesity. The consensus is that physical exercise should be part of the treatment of diabetes mellitus (DM). OBJECTIVE To compare the influence of guided and structured physical exercise programs (SPEP), three to five times per week, during a period...

The basic-helix-loop-helix-leucine-zipper domains of the c-Myc oncoprotein and its obligate partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. We have identified the binding sites and determined the structural means by which two unrelated small molecules, 10058-F4 and 10074-G5, bind c-Myc and stabilize the ID monomer over the...

A high-speed interface has been designed for interconnection of the S/390 I/O subsystem to the IBM S/390 G5 processor. The self-timed interface (STI) provides high bandwidth, greater communication distances, and simpler timing within the S/390 servers than traditional interfaces. The STI communicates between the memory bus adapter and the expanded S/390 I/O subsystem, which now includes the new...

The comments I offer in this memorandum on the MAC’s recommendations are limited to the issues listed below. In many cases, I agree with the MAC’s recommendations, and offer comments in order to contribute to broader debates about climate policy design in California, which will continue for years to come. There are also instances where I disagree with the MAC’s conclusions or believe the MAC fa...

Train-to-train communication will be the key technology for future railway operation. An increase of safety and efficiency can be achieved by exchanging data between trains via ad hoc networks. For vehicle-to-vehicle communication the European standard is intelligent transport systems (ITS-G5). The usage of this standard for railways is hardly investigated. We investigate the performance of ITS...

OBJECTIVE Hydroxyl (OH-) and calcium (Ca++) ion release was evaluated in six materials: G1) Sealer 26, G2) White mineral trioxide aggregate (MTA), G3) Epiphany, G4) Epiphany + 10% calcium hydroxide (CH), G5) Epiphany + 20% CH, and G6) zinc oxide and eugenol. MATERIAL AND METHODS Specimens were placed in polyethylene tubes and immersed in distilled water. After 3, 6, 12, 24, and 48 h, 7, 14, a...

Here, we use telomerase-deficient mice, Terc(-/-), to study the impact of telomerase abrogation in response to treatment with the alkylating agent N-Methyl-N-Nitrosourea (MNU), a potent carcinogen in the mouse. Wild-type mice treated with MNU developed lymphomas and carcinomas. In contrast, similarly treated G5 Terc(-/-) mice with critically short telomeres did not develop tumors and died of ac...

The paper investigates the eeective performance attainable for a speciic class of application programs on shared memory supercomputers. Speciically, we are to investigate how seismic data analysis applications behave on the Kendall Square Research Inc.'s KSR multiprocessors. The computational kernel of seismic computation algorithms is parallelized and its performance is analyzed. Three approac...