HCN channels play a unique role in bilaterian physiology as the only hyperpolarization-gated cation channels. Their voltage-gating is regulated by cyclic nucleotides and phosphatidylinositol 4,5-bisphosphate (PIP2). Activation of HCN channels provides the depolarizing current in response to hyperpolarization that is critical for intrinsic rhythmicity in neurons and the sinoatrial node. Addition...

Hydrogen cyanide (HCN) has been identified in the gas phase of the interstellar medium as well as in the comae of several comets. Terrestrially, HCN is a key component in the synthesis of biologically important molecules such as amino acids. In this paper, we report the results of low-temperature (18 K) ice energetic processing experiments involving pure HCN and mixtures of HCN with H2O and NH3...

Seedlings of both KS8 and N32 sorghum [Sorghum bicolor (L.) Moench] were high in dhurrin [p-hydroxy-(S)-mandelonitrile-BD-glucoside] and thus in hydrocyanic acid potential (HCN-p), but the HCN-p of mature leaves from field-grown plants of KS8 was only about one-tenth as high as that of N32. A study of the inheritance of this large difference between KS8 and N32 revealed that a single major gene...

the presented study shows a simple way for optimization of extrusion process, which was used for deterioration of cyanogenic glycosides – antinutritive components of linseed, with minimum damage of essential alpha-linolenic acid (ala) at the same time. extrusion of the material was done on a laboratory single screw extruder. content of hydrogen cyanide (hcn) as a measurement of cyanogenic glyco...

Hyperpolarization-activated, cyclic nucleotide-gated, nonspecific cation (HCN) channels have a well-characterized role in regulation of cellular excitability and network activity. The role of these channels in control of epileptiform discharges is less thoroughly understood. This is especially pertinent given the altered HCN channel expression in epilepsy. We hypothesized that inhibition of HCN...

It is widely accepted that the induction dose of anesthetics is higher in infants than in adults, although the relevant molecular mechanism remains elusive. We previously showed neuronal hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to hypnotic actions of propofol and ketamine. Interestingly, the expression of HCN channels in neocortex significantly changes duri...

HCN cation channel mRNA expression was determined in the rabbit heart and neonatal and adult rat ventricle using RNase protection assays. In the rabbit SA node, the dominant HCN transcript is HCN4, representing >81% of the total HCN message. HCN1 is also expressed, representing >18% of the total HCN mRNA. Rabbit Purkinje fibers contained almost equal amounts of HCN1 and HCN4 transcripts with lo...

We present radio-interferometric observations of HCN J = 1 → 0 line emission from the carbon star R Scl, obtained with the interim 3-mm receivers of the Australia Telescope Compact Array. The emission is resolved into a central source with a Gaussian FWHM of ∼1 ′′ , which we identify as the present mass loss envelope. Using a simple photodissociation model and constraints from single-dish HCN s...

We present new HCN and HCO + ( J = 3–2) images of the nearby star-forming galaxies (SFGs) NGC 3351, 3627, 4321. The observations, obtained with Morita ALMA Compact Array, have a spatial resolution ∼290–440 pc resolve inner R gal ≲ 0.6–1 kpc targets, as well southern bar end 3627. complement this data set publicly available lower excitation lines HCN, , CO analyse behaviour representative line r...

A growing body of research suggests that impaired bladder Cajal-like interstitial cells (ICCs) are a important component in the pathogenesis of diabetes-induced bladder dysfunction, although the molecular mechanisms have not been illustrated completely. The purpose of this study was to examine whether the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in ICCs-DM were respons...