Hepatitis C virus (HCV) is a major public health problem with more than 130-180 million people infected worldwide. Several studies in different populations have reported the association of human leukocyte antigen (HLA) genotypes, and HCV viral load, and genotypes. The aim of this study was to investigate a possible association between HLA class I and II alleles in HCV-infected patients and heal...

results the highest prevalent genotype was genotype 4a, which was found in 57 patients (92%) followed by 2 isolates (3%) with genotype 4o, 2 strains (3%) with genotype 1g and one isolate (2%) with genotype 4n. conclusions this molecular epidemiology study revealed high prevalence of hcv genotype 4, subtype 4a among egyptian patients residing in sharkia governorate, egypt. patients and methods t...

Background and Aims: Hepatitis C virus (HCV) is a member of the Flaviviridae family, which causes approximately 500,000 deaths annually. HCV infection treatment is often associated with significant adverse effects. Curcumin is an active ingredient of turmeric which has therapeutic anti-inflammatory effects in many diseases including infectious ones. Although curcumin is not soluble in water, if...

Hepatitis C virus (HCV) enters human hepatocytes through a multistep mechanism involving, among other host proteins, the virus receptor CD81. How CD81 governs HCV entry is poorly characterized, and CD81 protein interactions after virus binding remain elusive. We have developed a quantitative proteomics protocol to identify HCV-triggered CD81 interactions and found 26 dynamic binding partners. A...

hepatitis c virus (hcv) has chronically infected million peoples worldwide. spontaneous viral clearance occurs in 25% of affected patients.  the standard regimen to treat hcv infection is the combination of pegylated interferon and ribavirin.

INTRODUCTION Hepatitis C virus (HCV), which was formerly described as the parenterally transmitted form of non-A, non-B hepatitis (NANBH), becomes a chronic disease in 50% of the cases. HCV can also be transmitted through intravenous drug abuse, sexual , and household contact. Hepatitis C virus is a single stranded RNA virus with some structural relations to the flavivirus family. Nucleic acid ...

epatitis C virus (HCV) was identified by molecular Hcloning of its RNA genome after conventional methods of virus identification failed. This failure was due to both low levels of HCV particles in the blood of infected patients and particle heterogeneity. HCV is a highly variable virus. In addition to 6 genotypes and more than 60 subtypes, HCV mutants circulate in the blood as millions of quasi...

A self-modulating mechanism by the hepatitis C virus (HCV) core protein has been suggested to influence the level of HCV replication, but current data on this subject are contradictory. We examined the effect of wild-type and mutated core protein on HCV IRES- and cap-dependent translation. The wild-type core protein was shown to inhibit both IRES- and cap-dependent translation in an in vitro sy...

Hepatitis C virus (HCV) is an enveloped, single-stranded RNA virus, belonging to the Flaviviridae family. HCV infection is a major cause of chronic hepatitis worldwide, leading to steatosis, liver cirrosis and hepatocellular carcinoma. Significant advances in understanding the mechanisms of HCV infection have been made since the development of a cell culture system reproducing the complete HCV ...