N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in combination with docetaxel compared to tamoxifen, anastrazole, and docetaxel monotherapies against MNU-induced mammary tumors in female Lewis rats. Treat...

Awareness has been shown to be a useful addition to standard epistemic logic for many applications. However, standard propositional logics for knowledge and awareness cannot express the fact that an agent knows that there are facts of which he is unaware without there being an explicit fact that the agent knows he is unaware of. We propose a logic for reasoning about knowledge of unawareness, b...

agent technology is an emerging and promising research area in software technology, which increasingly contributes to the development of value-added information systems for large healthcare organizations due to its capability to automatically modify themselves in response to changes in their operating environment. multi agent system (mas) approach is the construction of a complex system as a se...

Background:Body packers occasionally refer to the Emergency Department (ED), after leakage of package contents within intestinal lumen, resulting in life-threatening toxicities, depending upon the nature of the chemical product. Case Presentation: We present a case report of a patient presented with sudden onset of drowsiness while he was on board a flight. He was brought in by the airport secu...

Current clinically approved thrombolytic agents have significant drawbacks including reocclusion and bleeding complications. To address these problems, a staphylokinase-based thrombolytic agent equipped with antithrombotic activity from hirudin was engineered. Because the N termini for both staphylokinase and hirudin are required for their activities, a Y-shaped molecule is generated using engi...

Clearly, if the agent is myopic, he will do badly in this decision problem: he will refuse the first exchange, which immediately stops the whole sequence. This means that the myopic agent will forgo a sure benefit of 3ε. His behaviour will be self-defeating. If the agent is resolute (cf. McClennen 1990 and 1997), each of the four possible outcomes is available to him. He can simply choose one o...

In this paper we introduce an ontology based on the notion of agent to represent and reason about social reality. We model social constructions as agents, for example, groups, organizations, normative systems, and roles, and we attribute mental attitudes to them. Roughly, we define obligations or regulative norms as goals of the normative system, constitutive norms as beliefs of the normative s...