AIM Short-acting insulin analogues, in comparison with regular human insulin (HRI), provide a greater control of postprandial glucose, while their superiority on haemoglobin A1c (HbA1c) is controversial. METHOD All randomized controlled trials (RCTs) with a duration >4 weeks comparing short-acting insulin analogues (lispro, aspart or glulisine) with HRI in type 2 diabetic patients were retrie...

Background: Unsafe food consumption is a severe problem because of heavy metal contamination, which is caused by director indirect activities of industries. The present study was conducted to assess the risk of human health by Heavy metals (Cu, Co, Fe, Zn and Mn) through the intake of vegetables and fishes obtained from the area adjacent to the Hazaribag tannery campus, Dhaka, Bangladesh. Resul...

Heme-regulated eukaryotic initiation factor 2 kinase (HRI) regulates the synthesis of hemoglobin in reticulocytes in response to heme availability. HRI contains a tightly bound heme at the N-terminal domain. Earlier reports show that nitric oxide (NO) regulates HRI catalysis. However, the mechanism of this process remains unclear. In the present study, we utilize in vitro kinase assays, optical...

Human ribonuclease inhibitor ~hRI! is a cytosolic protein that protects cells from the adventitious invasion of pancreatictype ribonucleases. hRI has 32 cysteine residues. The oxidation of these cysteine residues to form disulfide bonds is a rapid, cooperative process that inactivates hRI. The most proximal cysteine residues in native hRI are two pairs that are adjacent in sequence: Cys94 and C...

Here we show that cells lacking the heme-regulated inhibitor (HRI) are highly resistant to infection by bacterial pathogens. By examining the infection process in wild-type and HRI null cells, we found that HRI is required for pathogens to execute their virulence-associated cellular activities. Specifically, unlike wild-type cells, HRI null cells infected with the gram-negative bacterial pathog...

Installation work of large inner/outer wall panel glasses increases the labor load and stress of workers and causes the danger of such accidents as falling and crane overturning. To solve this problem, Gil designed the easy handling robot system which is composed of mobile system, 5-DOF manipulator system and HRI (Human-Robot Interface) device included HRC (Human-Robot Cooperation) algorithm. D...

background: to evaluate the present status of blood utilization and develop practice guidelines in teaching hospitals in northern iran. methods: we retrospectively analyzed the amount of blood prepared and used preoperatively for 11 elective procedures, from march 2010 to march 2011 in teaching hospitals in northern iran. study variables included the crossmatch transfusion ratio, the transfusio...

The ratio of nonsynonymous to synonymous substitution rates (ω) is often used to measure the strength of natural selection. However, ω may be influenced by linkage among different targets of selection, that is, Hill-Robertson interference (HRI), which reduces the efficacy of selection. Recombination modulates the extent of HRI but may also affect ω by means of GC-biased gene conversion (gBGC), ...

In the current study, quality of groundwater used for drinking purposes was assessed in Taluka Ghorābāri, Sindh, Pakistan. Twenty-five sampling locations were selected collection groundwater. Samples analyzed physicochemical and heavy metal analysis, followed by standard methods. Detection metals conducted using Atomic Absorption Spectrophotometer. Heavy which exceeded WHO safe limit included C...