BACKGROUND The adult mammalian heart responds to cardiac injury by formation of persistent fibrotic scar that eventually leads to heart failure. In contrast, the neonatal mammalian heart reacts to injury by the development of transient fibrotic tissue that is eventually replaced by regenerated cardiomyocytes. How fibrosis occurs in the neonatal mammalian heart remains unknown. To start elucidat...

In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the disease 2019 (COVID-19) pandemic, which has resulted in devastating conditions worldwide. In addition affecting system, COVID-19 affects other systemic organs, and particular, cardiovascular failure is related worsening of symptoms death. Among these, cardiac insufficiency seems be an important prognostic fa...

background: it has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. however, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in isch...

objectives: wheelchairs are the prime mobility aid of persons with spinal cord injuries. manual wheelchair propulsion puts a lot of demand on the cardiopulmonary as well as the skeletal system. the main purpose of the study was to compare the effects of both arm ergometry training and progressive resistance exercise training of upper limbs on resting heart rate and distance covered during wheel...

1. To recognise that acute myocardial ischaemia/reperfusion injury is a neglected therapeutic target for cardioprotection that is responsible for the ongoing morbidity and mortality of patients with ischaemic heart disease. 2. To be aware that cardiac bypass surgery and STEMI are the major clinical settings in which the heart is subjected to acute ischaemia/reperfusion injury. 3. To be familiar...

Objective(s): Acute lung injury (ALI) has a high mortality rate and is characterized by damage to pulmonary system giving rise to symptoms such as histological alteration, lung tissue edema and production of proinflammatory cytokine. p-Coumaric acid (p-CA), as a phenolic compound, that is found in many types of fruits and vegetables has been reported to exhibit a thera...

Over 160 cases of injury to the heart by pins and needles have been reported (Hermoni et al., 1986). These objects reached the heart by a number of routes including embolization and penetration from adjacent organs after ingestion. However the most common mode of injury was by direct transthoracic penetration and the majority of these were accidental in nature. We present the history of a 22-ye...

Cardiac impalement injury is rare and one of the most severe penetrating chest injuries, often fatal. The management of penetrating cardiac injuries is a challenging one. The success in management of impaling cardiac trauma requires stabilization of the impaling object, expeditious transfer to a facility for open heart surgery, rapid imaging, access to blood and blood products and a ready surgi...