نتایج جستجو برای: heffron
تعداد نتایج: 53 فیلتر نتایج به سال:
Definitions of spatial data infrastructure (SDI), and claims about its value, emphasise applications that solve real societal issues as the ultimate benefit. While it may be premature to expect that those benefits show up in many SDIs (if in any, by now), preparing for systematic evaluation is timely. Initiatives like the Spatial Data Interest Community on Monitoring and Reporting, in conjuncti...
Functional genomic screening reveals asparagine dependence as a 1 metabolic vulnerability in sarcoma
44 Current therapies for sarcomas are often inadequate. This study sought to 45 identify actionable gene targets by selective targeting of the molecular networks 46 that support sarcoma cell proliferation. Silencing of asparagine synthetase 47 (ASNS), an amidotransferase that converts aspartate into asparagine, produced 48 the strongest inhibitory effect on sarcoma growth in a functional genomi...
The adenylate cyclase hemolysin toxin (ACT) is one of the main virulence factors in Bordetella pertussis. It was discovered in 1973 by Wolff and Cook as a contaminant in vaccine formulations against this microorganism. It belongs to the family of toxins that form pores at the plasma membrane of target cells and reaches the highest expression during the virulent phase of the bacteria. This toxin...
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